Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9969606 | 0.80 | ALDH1A1 (0.38) | ALDH1A1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL5113756 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL6004785 | 0.78 | IDO1 (0.44) | ALDH1A1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL4404861 | 0.77 | IDO1 (0.57) | ALDH1A1HPGDMAPTTSHRIDO1 | |
| SCHEMBL14183585 | 0.77 | L3MBTL1 (0.36) | ALDH1A1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL14832848 | 0.76 | ADRB2 (0.33) | ALDH1A1ADRB2ADRB1ADRB3HPGD | |
| SCHEMBL20279744 | 0.76 | MAPT (0.35) | ALDH1A1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL19938075 | 0.75 | CYP3A4 (0.51) | ALDH1A1KDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL13866298 | 0.75 | MMP2 (0.44) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL13866315 | 0.75 | MMP2 (0.44) | ALDH1A1HPGDMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081278-A1 | Novel compounds | GLAXO GROUP LIMITED (GB) | 2017-03-23 | — | — | US | disclosed |
| US-9540318-B2 | Sulfonamide compounds and their use in the modulation retinoid-related orphan receptor | GLAXO GROUP LIMITED (GB) | 2017-01-10 | — | — | US | disclosed |
| US-20150361039-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID-RELATED ORPHAN RECEPTOR | GLAXO GROUP LIMITED (GB) | 2015-12-17 | — | — | US | disclosed |
| US-9150508-B2 | Sulfonamide compounds and their use in the modulation retinoid-related orphan receptor | GLAXO GROUP LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-20140243362-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID-RELATED ORPHAN RECEPTOR | GLAXO GROUP LIMITED (GB) | 2014-08-28 | — | — | US | disclosed |
| EP-2760443-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID - RELATED ORPHAN RECEPTOR | Glaxo Group Limited (GB) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045431-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID - RELATED ORPHAN RECEPTOR | GLAXO GROUP LIMITED (GB) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170081278-A1 | Novel compounds | RORC, RORB, RORA | ALDH1A1 913/4885KDM4E 1990/4885ADRB2 491/4885 |
| US-20150361039-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID-RELATED ORPHAN RECEPTOR | RORA, RORC, RORB | ALDH1A1 940/4885KDM4E 2349/4885ADRB2 727/4885 |
| US-20140243362-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID-RELATED ORPHAN RECEPTOR | RORA, RORB, RORC | ALDH1A1 686/4885KDM4E 1912/4885ADRB2 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.