Sugi Predict

Sugi Predict / Compounds / SCHEMBL14844549

SCHEMBL14844549

SCHEMBL14844549

COc1c(Cl)cnn(C)c1=O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.56
▸ HPGD P15428 1/20 0.56
▸ GAA P10253 1/20 0.56
▸ KMT2A Q03164 2/20 0.54
▸ KAT2B Q92831 2/20 0.46
▸ BRD9 Q9H8M2 1/20 0.46
▸ BPTF Q12830 1/20 0.44
▸ NPBWR1 P48145 9/20 0.43
▸ SMN1; SMN2 Q16637 3/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ S1PR4 O95977 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ S1PR1 P21453 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ PAX8 Q06710 1/20 0.42
▸ MCHR1 Q99705 4/20 0.41
▸ NPSR1 Q6W5P4 3/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18532426 0.80 GAA (0.56) ALDH1A1GAAKMT2ANPBWR1SMN1; SMN2
SCHEMBL14844575 0.80 NPBWR1 (0.43) ALDH1A1HPGDGAAKMT2AKAT2B
SCHEMBL15569608 0.79 ALDH1A1 (0.49) ALDH1A1HPGDGAAKMT2AKAT2B
SCHEMBL14844559 0.78 GAA (0.50) ALDH1A1GAAKMT2ANPBWR1HTT
SCHEMBL979278 0.77 KAT2B (0.60) ALDH1A1HPGDGAAKMT2AKAT2B
SCHEMBL1376441 0.76 GAA (0.51) ALDH1A1HPGDGAAKMT2ANPBWR1
Hydrochloric Acid SCHEMBL17912386 0.75 KAT2B (0.58) ALDH1A1HPGDGAAKMT2AKAT2B
SCHEMBL2642056 0.75 KAT2B (0.53) ALDH1A1HPGDKAT2BBRD9BPTF
SCHEMBL8544499 0.75 BRD9 (0.48) ALDH1A1HPGDGAAKAT2BBRD9
SCHEMBL466352 0.74 ALDH1A1 (0.55) ALDH1A1HPGDGAAKAT2BBRD9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435044-B2 Pyridazinone herbicides and pyridazinone intermediates used to prepare a herbicide FMC CORPORATION (US) 2025-10-07 — — US disclosed
CN-119039233-A Pyridazinone herbicides and pyridazinone intermediates for preparing the same FMC公司 2024-11-29 — — CN disclosed
CN-118994028-A Pyridazinone herbicides and pyridazinone intermediates for preparing the same FMC公司 2024-11-22 — — CN disclosed
CN-113166075-B Pyridazinone herbicides and pyridazinone intermediates for preparing the same FMC公司 2024-10-25 — — CN disclosed
EP-4035528-B1 7-OXA-3,4-DIAZABICYCLO[4.1.0]HEPT-4-EN-2-ONE COMPOUND AND HERBICIDE NIPPON SODA CO (JP) 2024-03-27 — — EP disclosed
US-20220289758-A1 7-OXA-3,4-DIAZABICYCLO [4.1.0] HEPT-4-EN-2-ONE COMPOUND AND HERBICIDE NIPPON SODA CO., LTD. (JP) 2022-09-15 — — US disclosed
EP-4035528-A1 7-OXA-3,4-DIAZABICYCLO[4.1.0]HEPTA-4-ENE-2-ONE COMPOUND AND HERBICIDE Nippon Soda Co., Ltd. (JP) 2022-08-03 — — EP disclosed
CN-114375292-A 7-oxa-3,4-diazabicyclo [4.1.0] hept-4-en-2-one compounds and herbicides 日本曹达株式会社 2022-04-19 — — CN disclosed
US-20220041560-A1 PYRIDAZINONE HERBICIDES AND PYRIDAZINONE INTERMEDIATES USED TO PREPARE A HERBICIDE FMC CORPORATION 2022-02-10 — — US disclosed
CN-113166075-A Pyridazinone herbicides and pyridazinone intermediates for the preparation thereof FMC公司 2021-07-23 — — CN disclosed
WO-2015177109-A1 5-(HETERO)ARYL-PYRIDAZINONES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2015-11-26 — — WO disclosed
US-9049864-B2 Pyridazinone herbicidal compounds SYNGENTA LIMITED (GB) 2015-06-09 — — US disclosed
EP-2836488-A1 PYRIDAZINONE HERBICIDAL COMPOUNDS Syngenta Limited (GB) 2015-02-18 — — EP disclosed
US-20150031540-A1 PYRIDAZINONE HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2015-01-29 — — US disclosed
WO-2014154828-A1 PYRIDAZINONE DERIVATIVES AS HERBICIDES SYNGENTA LIMITED (GB) 2014-10-02 — — WO disclosed
US-20140256546-A1 HERBICIDAL PYRIDAZINONE DERIVATIVES SYNGENTA LIMITED (GB) 2014-09-11 — — US disclosed
EP-2763968-A1 HERBICIDAL PYRIDAZINONE DERIVATIVES Syngenta Limited (GB) 2014-08-13 — — EP disclosed
CN-103874688-A Herbicidal pyridazinone derivatives SYNGENTA LTD 2014-06-18 — — CN disclosed
WO-2013160126-A1 PYRIDAZINONE HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2013-10-31 — — WO disclosed
WO-2013050421-A1 HERBICIDAL PYRIDAZINONE DERIVATIVES SYNGENTA LIMITED (GB) 2013-04-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150031540-A1 PYRIDAZINONE HERBICIDAL COMPOUNDS PDXK, PRDX6, PRDX1 ALDH1A1 292/4885HPGD 603/4885GAA 692/4885
US-12435044-B2 Pyridazinone herbicides and pyridazinone intermediates used to prepare a herbicide CBR3, CBR1, CYP4F3 ALDH1A1 701/4885HPGD 477/4885GAA 3410/4885
US-20140256546-A1 HERBICIDAL PYRIDAZINONE DERIVATIVES PRDX6, PRDX1, CBR3 ALDH1A1 861/4885HPGD 3113/4885GAA 2637/4885
US-20220041560-A1 PYRIDAZINONE HERBICIDES AND PYRIDAZINONE INTERMEDIATES USED TO PREPARE A HERBICIDE CBR3, CBR1, CYP4F3 ALDH1A1 701/4885HPGD 477/4885GAA 3410/4885
US-20220289758-A1 7-OXA-3,4-DIAZABICYCLO [4.1.0] HEPT-4-EN-2-ONE COMPOUND AND HERBICIDE DDT, OXA1L, CYP8B1 ALDH1A1 263/4885HPGD 3586/4885GAA 1565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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