Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9079605 | 0.98 | LMNA (0.52) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL20284601 | 0.91 | AKR1C3 (0.47) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL164538 | 0.87 | LMNA (0.67) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL576454 | 0.87 | LMNA (0.67) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL16924853 | 0.87 | LMNA (0.67) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL576814 | 0.87 | LMNA (0.67) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL385012 | 0.87 | — | — | |
| SCHEMBL7258870 | 0.84 | LMNA (0.64) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL576673 | 0.79 | LMNA (0.58) | LMNASIGMAR1HTR3EHTR3BADRB1 | |
| SCHEMBL577708 | 0.79 | LMNA (0.58) | LMNASIGMAR1HTR3EHTR3BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344512-A | Mannich base and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-116178880-B | Preparation method of intumescent flame retardant modified ABS resin | 揭阳市万润新材料有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-116354901-A | Thiazolidinedione compound and preparation method and application thereof | 郑州大学 | 2023-06-30 | — | — | CN | claimed |
| CN-116178880-A | Preparation method of intumescent flame retardant modified ABS resin | 揭阳市万润新材料有限公司 | 2023-05-30 | — | — | CN | claimed |
| EP-2057137-B1 | S-(+)-7-[3-N-SUBSTITUTED AMINO-2-HYDROXYPROPOXY]FLAVONES | COUNCIL SCIENT IND RES (IN) | 2013-10-23 | — | — | EP | claimed |
| US-20110077294-A1 | R-(-) / S-(+)-7-[3-N SUBSTITUTED AMINO-2 HYDROXYPROPOXY] FLAVONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2011-03-31 | — | — | US | claimed |
| US-20110065703-A1 | NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS | VM THERAPEUTICS LLC | 2011-03-17 | — | — | US | claimed |
| CN-101686952-A | Novel agents of calcium ion channel modulators | VM DISCOVERY INC | 2010-03-31 | — | — | CN | claimed |
| EP-2073799-A2 | NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS | VM Discovery, Inc. (US) | 2009-07-01 | — | — | EP | claimed |
| EP-2057137-A1 | R-(-) / S-(+)-7-[3-N-SUBSTITUTED AMINO-2-HYDROXYPROPOXY]FLAVONES | Council of Scientific and Industrial Research (IN) | 2009-05-13 | — | — | EP | claimed |
| WO-2008018089-A1 | R-(-) / S-(+)-7-[3-N-SUBSTITUTED AMINO-2-HYDROXYPROPOXY] FLAVONES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-02-14 | — | — | WO | claimed |
| EP-1807408-A1 | OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS | Council of Scientific and Industrial Research (IN) | 2007-07-18 | — | — | EP | claimed |
| US-20060281733-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. | 2006-12-14 | — | — | US | claimed |
| US-20060178373-A1 | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2006-08-10 | — | — | US | claimed |
| US-20060142303-A1 | Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents | PRATAP RAM | 2006-06-29 | — | — | US | claimed |
| WO-2006040621-A1 | OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-04-20 | — | — | WO | claimed |
| EP-1633348-A1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | claimed |
| US-20050020659-A1 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. | 2005-01-27 | — | — | US | claimed |
| WO-2004098589-A1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARMACEUTICALS, INC. (US) | 2004-11-18 | — | — | WO | claimed |
| US-3981868-A | MICROBIOCIDES, HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1976-09-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077294-A1 | R-(-) / S-(+)-7-[3-N SUBSTITUTED AMINO-2 HYDROXYPROPOXY] FLAVONES | HTR7, PNMT, PRMT7 | LMNA 3555/4885SIGMAR1 104/4885HTR3E 14/4885 |
| US-20050020659-A1 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | BDKRB1, BDKRB2, BRS3 | LMNA 1562/4885SIGMAR1 1470/4885HTR3E 833/4885 |
| US-20110065703-A1 | NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS | CACNA1G, CACNA1C, CACNA1B | LMNA 2068/4885SIGMAR1 2739/4885HTR3E 1263/4885 |
| US-20060142303-A1 | Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents | LIPC, CYP46A1, HMGCR | LMNA 2229/4885SIGMAR1 509/4885HTR3E 1994/4885 |
| US-20060178373-A1 | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents | GPR119, LIPC, SLC5A2 | LMNA 2167/4885SIGMAR1 1346/4885HTR3E 2112/4885 |
| US-20060281733-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | BDKRB1, BDKRB2, CNR1 | LMNA 2720/4885SIGMAR1 2314/4885HTR3E 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.