Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17070902 | 0.80 | KDM4E (0.51) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL9273442 | 0.76 | KDM5A (0.41) | ALDH1A1MAPTKDM4ELMNAL3MBTL1 | |
| SCHEMBL1861019 | 0.72 | MAPT (0.43) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL13966823 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL10216413 | 0.70 | MAPT (0.44) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL17131847 | 0.69 | LMNA (0.53) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL21027734 | 0.68 | MAPT (0.43) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL19530909 | 0.67 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4ECYP1A2LMNA | |
| SCHEMBL13492907 | 0.67 | ADORA2A (0.36) | ALDH1A1MAPTKDM4ECYP1A2CYP2C19 | |
| Methoxymethane SCHEMBL28044932 | 0.66 | MAPT (0.39) | ALDH1A1MAPTKDM4ECYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776402-B1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | UNIV JOHNS HOPKINS (US) | 2017-07-26 | — | — | EP | disclosed |
| US-9499511-B2 | N-substituted hydroxylamine derivatives with carbon-based leaving groups | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499511-B2 | N-substituted hydroxylamine derivatives with carbon-based leaving groups | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-11-22 | — | — | US | disclosed |
| US-20160115148-A1 | N-SUBSTITUTED HYDROXYLAMINE DERIVATIVES WITH CARBON-BASED LEAVING GROUPS | NATIONAL SCIENCE FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| US-20160115148-A1 | N-SUBSTITUTED HYDROXYLAMINE DERIVATIVES WITH CARBON-BASED LEAVING GROUPS | NATIONAL SCIENCE FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| US-9181213-B2 | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-11-10 | — | — | US | disclosed |
| US-9181213-B2 | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-11-10 | — | — | US | disclosed |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | NATIONAL SCIENCE FOUNDATION | 2014-09-18 | — | — | US | disclosed |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | NATIONAL SCIENCE FOUNDATION | 2014-09-18 | — | — | US | disclosed |
| WO-2013059194-A1 | MELDRUM 'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | JOHNS HOPKINS UNIVERSITY (US) | 2013-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115148-A1 | N-SUBSTITUTED HYDROXYLAMINE DERIVATIVES WITH CARBON-BASED LEAVING GROUPS | NOS2, NOS3, HMOX2 | ALDH1A1 453/4885MAPT 4557/4885KDM4E 1344/4885 |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | HMOX1, HMOX2, HPGD | ALDH1A1 515/4885MAPT 3459/4885KDM4E 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.