Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28074698 | 0.84 | TTR (0.48) | TP53TTRCES1MGLLGABRA1 | |
| SCHEMBL10045010 | 0.82 | TTR (0.47) | TP53TTRCES1MGLLGABRA1 | |
| SCHEMBL9728198 | 0.69 | MGLL (0.42) | TP53MGLLGABRA1GABRB2LMNA | |
| SCHEMBL28490612 | 0.69 | NR1H2 (0.54) | TTRCES1ALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL13607734 | 0.66 | PARP1 (0.40) | TTRCES1LMNAMAPTMEN1 | |
| SCHEMBL13671328 | 0.65 | MEN1 (0.60) | MAPTMEN1KMT2AANPEPDPP4 | |
| SCHEMBL28551734 | 0.63 | MGLL (0.36) | TP53MGLLGABRA1GABRB2LMNA | |
| SCHEMBL7756746 | 0.63 | TTR (0.52) | TTRCES1MGLLLMNAMEN1 | |
| SCHEMBL29717667 | 0.61 | ALDH1A1 (0.44) | TP53CES1MGLLMAPTMEN1 | |
| SCHEMBL15206754 | 0.61 | TTR (0.50) | TTRCES1MGLLLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871936-B2 | Method for manufacturing of quinoline-3-carboxamides | ACTIVE BIOTECH AB (SE) | 2014-10-28 | — | — | US | disclosed |
| US-20130109860-A1 | METHOD FOR MANUFACTURING OF QUINOLINE-3-CARBOXAMIDES | ACTIVE BIOTECH AB (SE) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109860-A1 | METHOD FOR MANUFACTURING OF QUINOLINE-3-CARBOXAMIDES | ADH1A, ADH5, ADH1C | TP53 4660/4885TTR 1922/4885CES1 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.