Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 5/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490630 | 0.78 | APP (0.46) | APP | |
| SCHEMBL1491024 | 0.76 | CES2 (0.52) | P4HBMAOB | |
| SCHEMBL402677 | 0.73 | P4HB (0.62) | P4HBRARARARBRARGHSD17B10 | |
| SCHEMBL1490943 | 0.73 | MEN1 (0.58) | HSD17B2HSP90AA1HSP90AB1HSD17B10ABCG2 | |
| SCHEMBL840795 | 0.72 | KIF11 (0.51) | P4HBHSD17B1HSP90AA1HSP90AB1RARA | |
| SCHEMBL30440431 | 0.72 | KIF11 (0.51) | P4HBHSD17B1HSP90AA1HSP90AB1RARA | |
| SCHEMBL4895466 | 0.72 | P4HB (0.47) | P4HBHSD17B1HSD17B2APPHSP90AA1 | |
| SCHEMBL2873637 | 0.72 | LCK (0.48) | P4HBHSD17B1HSD17B2HSP90AA1HSP90AB1 | |
| SCHEMBL4314105 | 0.71 | P4HB (0.44) | P4HBHSD17B1HSD17B2APPHSP90AA1 | |
| SCHEMBL9464150 | 0.70 | LMNA (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477698-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | Centre National de la Recherche Scientifique (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033115-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-24 | — | — | WO | disclosed |