Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL19899711 | 0.92 | TDP1 (0.41) | — | |
| Potassium Ion SCHEMBL9089761 | 0.92 | — | — | |
| Lithium Ion SCHEMBL9090012 | 0.92 | — | — | |
| Silver SCHEMBL19899724 | 0.92 | — | — | |
| Benzenethiol SCHEMBL11013381 | 0.75 | TSHR (0.32) | — | |
| SCHEMBL2962836 | 0.70 | — | — | |
| SCHEMBL28069 | 0.70 | — | — | |
| SCHEMBL3808897 | 0.67 | — | — | |
| SCHEMBL9161603 | 0.67 | — | — | |
| SCHEMBL1820268 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60209562-A | — | — | None | — | — | JP | disclosed |
| US-10828371-B2 | Multifunctionalized bioactive polycaprolactone | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190134209-A1 | MULTIFUNCTIONALIZED BIOACTIVE POLYCAPROLACTONE | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2019-05-09 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| EP-2440542-B1 | Substituted benzimidazoles, benzonthiazoles and benzoxazoles | GRUENENTHAL GMBH (DE) | 2013-12-18 | — | — | EP | disclosed |
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| EP-2611810-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE DERIVATIVES | Grünenthal GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-8357717-B2 | Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity | GRUENENTHAL GMBH (DE) | 2013-01-22 | — | — | US | disclosed |
| US-8232288-B2 | Substituted benzimidazoles, benzothiazoles and benzoxazoles | GRUENENTHAL GMBH (DE) | 2012-07-31 | — | — | US | disclosed |
| WO-2002032856-A2 | INSECTICIDAL 1,8-NAPHTHALENEDICARBOXAMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-04-25 | — | — | WO | disclosed |
| WO-2001085709-A2 | NEW COMPOUNDS HAVING ANTICANCER ACTIVITY: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2001-11-15 | — | — | WO | disclosed |
| US-5489613-A | TREATING THROMBOSIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-06 | — | — | US | disclosed |
| US-5405870-A | Platelet-aggregation inhibitors; useful in treatment of thrombosis | SANKYO COMPANY, LIMITED (JP) | 1995-04-11 | — | — | US | disclosed |
| US-5075327-A | Antipsoriatic agents | HOFFMANN-LA ROCHE INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0211954-B1 | USE OF (+/-)-CIS-GAMMA-IRONE IN PERFUMERY AND NOVEL PROCESS FOR PREPARING SAME | T. HASEGAWA COMPANY, LTD. (JP) | 1991-07-17 | — | — | EP | disclosed |
| EP-0136779-B1 | NEW CARBACYCLIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1988-09-14 | — | — | EP | disclosed |
| JP-S60209562-A | PRODUCTION OF (+-)-CIS-GAMMA-TRONE AND ITS UTILIZATION | T HASEGAWA CO LTD | 1985-10-22 | — | — | JP | disclosed |
| EP-0136779-A1 | New carbacyclin derivatives, processes for their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-04-10 | — | — | EP | disclosed |
| US-3970676-A | Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes | THE UPJOHN COMPANY (US) | 1976-07-20 | — | — | US | disclosed |