SCHEMBL14949074

SCHEMBL14949074

CNC(Cc1c(F)c(F)c(F)c(F)c1F)C(=O)C(C)C

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.37
MMP2 P08253 2/20 0.36
MMP3 P08254 2/20 0.36
MMP1 P03956 1/20 0.36
PKM P14618 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
OPRD1 P41143 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
TAS1R2 Q8TE23 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12411251 0.84 CTSS (0.36) CTSSMMP2MMP3MMP1PKM
SCHEMBL15185807 0.84 CTSS (0.36) CTSSMMP2MMP3MMP1PKM
SCHEMBL10065865 0.81 CTSS (0.41) CTSSMMP2MMP3MMP1PKM
SCHEMBL14898392 0.81 CTSS (0.38) CTSSMMP2MMP3MMP1PKM
SCHEMBL19790147 0.81 CTSS (0.38) CTSSMMP2MMP3MMP1PKM
SCHEMBL14010002 0.80 TAS1R3 (0.36) CTSSMMP2MMP3MMP1TAS1R3
SCHEMBL18855074 0.80 TAS1R3 (0.38) CTSSTAS1R3TAS1R1TAS1R2
SCHEMBL25908942 0.75 TAS1R3 (0.37) CTSSMMP2MMP3MMP1OPRD1
SCHEMBL25847752 0.74 TRPA1 (0.46) CTSS
SCHEMBL24960115 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130123170-A1 Growth Hormone Releasing Peptides IPSEN PHARMA, S.A.S. (FR) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123170-A1 Growth Hormone Releasing Peptides GHRHR, THRB, PRLHR CTSS 4127/4885MMP2 3935/4885MMP3 3638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.