SCHEMBL14010002

SCHEMBL14010002

Cc1c(F)c(F)c(F)c(CC(NC(C)C)C(=O)C(C)C)c1F

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 8/20 0.36
TAS1R1 Q7RTX1 8/20 0.36
TAS1R2 Q8TE23 8/20 0.36
CTSS P25774 1/20 0.33
MMP2 P08253 2/20 0.30
MMP3 P08254 2/20 0.30
MMP1 P03956 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18855074 0.97 TAS1R3 (0.38) TAS1R3TAS1R1TAS1R2CTSS
SCHEMBL12411251 0.92 CTSS (0.36) CTSSMMP2MMP3MMP1
SCHEMBL15185807 0.92 CTSS (0.36) CTSSMMP2MMP3MMP1
SCHEMBL14949074 0.80 CTSS (0.37) TAS1R3TAS1R1TAS1R2CTSSMMP2
SCHEMBL25908942 0.74 TAS1R3 (0.37) TAS1R3TAS1R1TAS1R2CTSSMMP2
SCHEMBL19361698 0.71 HDAC3 (0.34)
SCHEMBL13254073 0.71 OPRM1 (0.37)
SCHEMBL26428476 0.71 OPRM1 (0.37)
SCHEMBL23306946 0.69 TRPA1 (0.45) CTSS
SCHEMBL25462622 0.69 ALDH1A1 (0.43) CTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170362275-A1 Growth Hormone Releasing Peptides IPSEN PHARMA S.A.S. (FR) 2017-12-21 US disclosed
US-20160311855-A1 Growth Hormone Releasing Peptides IPSEN PHARMA S.A.S. (FR) 2016-10-27 US disclosed
US-9475837-B2 Process for the synthesis of therapeutic peptides IPSEN MANUFACTURING IRELAND LIMITED (IE) 2016-10-25 US disclosed
US-20150045534-A1 Process for the Synthesis of Therapeutic Peptides IPSEN MANUFACTURING IRELAND LIMITED (IE) 2015-02-12 US disclosed
US-8859729-B2 Growth hormone releasing peptides IPSEN PHARMA S.A.S. (FR) 2014-10-14 US disclosed
US-20130210751-A1 Pharmaceutical Compositions of Growth Hormone Secretagogue Receptor Ligands IPSEN PHARMA, S.A.S. (FR) 2013-08-15 US disclosed
US-20130123170-A1 Growth Hormone Releasing Peptides IPSEN PHARMA, S.A.S. (FR) 2013-05-16 US disclosed
US-8377865-B2 Peptidomimetics ; determine ability to bind to growth hormone secretagogue; ghrelin antagonist; appetite stimulation; dietetics ; weight maintenance; eating disorders IPSEN PHARMA S.A.S. (FR) 2013-02-19 US disclosed
US-7456253-B2 Peptidomimetics; determining ability to bind growth hormone secretagogue; ghrelin agonists; appetite stimulation; dietetics SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, SAS (FR) 2008-11-25 US disclosed
US-20080242619-A1 Growth hormone releasing peptides BIOMEASURE, INCORPORATED 2008-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160311855-A1 Growth Hormone Releasing Peptides GHRHR, THRB, PRLHR TAS1R3 1838/4885TAS1R1 2209/4885TAS1R2 2259/4885
US-20080242619-A1 Growth hormone releasing peptides GHRHR, THRB, PRLHR TAS1R3 1586/4885TAS1R1 1904/4885TAS1R2 1984/4885
US-20150045534-A1 Process for the Synthesis of Therapeutic Peptides MAX, VIP, SFPQ TAS1R3 2143/4885TAS1R1 2591/4885TAS1R2 2451/4885
US-20130123170-A1 Growth Hormone Releasing Peptides GHRHR, THRB, PRLHR TAS1R3 1838/4885TAS1R1 2209/4885TAS1R2 2259/4885
US-20130210751-A1 Pharmaceutical Compositions of Growth Hormone Secretagogue Receptor Ligands GHSR, GHRHR, SSTR5 TAS1R3 1242/4885TAS1R1 1039/4885TAS1R2 1199/4885
US-20170362275-A1 Growth Hormone Releasing Peptides GHRHR, THRB, PRLHR TAS1R3 1838/4885TAS1R1 2209/4885TAS1R2 2259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.