Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499012 | 0.81 | RAPGEF4 (0.30) | — | |
| SCHEMBL19636607 | 0.79 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL3450618 | 0.78 | PDGFRB (0.37) | ALDH1A1TSHR | |
| SCHEMBL13088223 | 0.77 | — | — | |
| SCHEMBL7633971 | 0.77 | — | — | |
| SCHEMBL24533522 | 0.73 | — | — | |
| SCHEMBL3693668 | 0.72 | TRPA1 (0.32) | — | |
| SCHEMBL27530767 | 0.72 | PDE2A (0.41) | ALDH1A1TSHR | |
| SCHEMBL16638710 | 0.71 | KMT2A (0.36) | — | |
| SCHEMBL15724447 | 0.71 | CA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967519-B1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2011-09-01 | — | — | US | disclosed |
| US-7906508-B2 | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity | JAPAN TOBACCO INC. (JP) | 2011-03-15 | — | — | US | disclosed |
| EP-1967519-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2008-09-10 | — | — | EP | disclosed |
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | ALDH1A1 1012/4885TSHR 1373/4885 |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | ALDH1A1 1012/4885TSHR 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.