Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10212099 | 0.87 | ACHE (0.44) | ACHESLC6A2HTR1ASLC6A4KCNH2 | |
| SCHEMBL4424952 | 0.80 | AR (0.41) | ARSMN1; SMN2 | |
| SCHEMBL20002022 | 0.79 | KMT2A (0.33) | KMT2AACHESLC6A2HTR1ASLC6A4 | |
| SCHEMBL19657135 | 0.78 | TDP1 (0.37) | KMT2AACHESLC6A2HTR1ASLC6A4 | |
| SCHEMBL8727533 | 0.77 | EPAS1 (0.34) | KMT2ASLC6A2HTR1ASLC6A4AR | |
| SCHEMBL16886233 | 0.76 | SLC6A2 (0.33) | KMT2ASLC6A2HTR1ASLC6A4AR | |
| SCHEMBL475141 | 0.76 | ALDH1A1 (0.46) | KMT2AACHESLC6A2SLC6A4NFE2L2 | |
| SCHEMBL14499012 | 0.75 | RAPGEF4 (0.30) | — | |
| SCHEMBL12719865 | 0.75 | L3MBTL1 (0.45) | SLC6A2HTR1ASLC6A4TDP1L3MBTL1 | |
| SCHEMBL24252074 | 0.75 | HTR2A (0.32) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640508-B2 | Diazene directed modular synthesis of compounds with quaternary carbon centers | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-05-05 | — | — | US | disclosed |
| US-20190119286-A1 | DIAZENE DIRECTED MODULAR SYNTHESIS OF COMPOUNDS WITH QUATERNARY CARBON CENTERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-04-25 | — | — | US | disclosed |
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170342077-A1 | DIAZENE DIRECTED MODULAR SYNTHESIS OF COMPOUNDS WITH QUATERNARY CARBON CENTERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-30 | — | — | US | disclosed |
| US-9771320-B2 | Carbocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771320-B2 | Carbocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20160326103-A1 | CARBOCYCLIC SULFONE ROR GAMMA MODULATORS | BRISTROL-MYERS SQUIBB COMPANY (US) | 2016-11-10 | — | — | US | disclosed |
| US-20150266856-A1 | RORGamma Modulators | EXELIXIS, INC. | 2015-09-24 | — | — | US | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266856-A1 | RORGamma Modulators | RORB, RORA, RORC | KMT2A 2212/4885ACHE 2770/4885SLC6A2 4557/4885 |
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | KMT2A 2258/4885ACHE 3334/4885SLC6A2 4710/4885 |
| US-20160326103-A1 | CARBOCYCLIC SULFONE ROR GAMMA MODULATORS | RORC, RORB, RORA | KMT2A 2551/4885ACHE 4255/4885SLC6A2 4762/4885 |
| US-20190119286-A1 | DIAZENE DIRECTED MODULAR SYNTHESIS OF COMPOUNDS WITH QUATERNARY CARBON CENTERS | CSPP1, CBR3, NPY2R | KMT2A 3359/4885ACHE 1089/4885SLC6A2 767/4885 |
| US-10640508-B2 | Diazene directed modular synthesis of compounds with quaternary carbon centers | CSPP1, CBR3, NPY2R | KMT2A 3359/4885ACHE 1089/4885SLC6A2 767/4885 |
| US-20170342077-A1 | DIAZENE DIRECTED MODULAR SYNTHESIS OF COMPOUNDS WITH QUATERNARY CARBON CENTERS | CSPP1, CBR3, NPY2R | KMT2A 3359/4885ACHE 1089/4885SLC6A2 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.