Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.72 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11871935 | 0.91 | CYP1A2 (0.56) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL2328960 | 0.89 | LMNA (0.82) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL29941729 | 0.89 | LMNA (0.82) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL10485650 | 0.86 | LMNA (0.68) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL14901599 | 0.85 | CYP1A2 (0.51) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL11819390 | 0.85 | CYP1A2 (0.53) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| SCHEMBL14112094 | 0.84 | LMNA (0.74) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| Guaifenesin SCHEMBL29759010 | 0.84 | CYP1A2 (1.00) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| Guaifenesin SCHEMBL4322 | 0.84 | CYP1A2 (1.00) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 | |
| Guaifenesin SCHEMBL4321 | 0.84 | CYP1A2 (1.00) | LMNACYP1A2AGTR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586774-A1 | METHOD FOR PREPARATION OF RANOLAZINE | Shanghai Kuoikee Laboratories Co., Ltd (CN) | 2013-05-01 | — | — | EP | disclosed |
| EP-2586774-A1 | METHOD FOR PREPARATION OF RANOLAZINE | Shanghai Kuoikee Laboratories Co., Ltd (CN) | 2013-05-01 | — | — | EP | disclosed |
| US-20130090475-A1 | Process for the Preparation of Ranolazine | ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-04-11 | — | — | US | disclosed |
| US-20130090475-A1 | Process for the Preparation of Ranolazine | ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-04-11 | — | — | US | disclosed |
| US-20130090475-A1 | Process for the Preparation of Ranolazine | ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-04-11 | — | — | US | disclosed |
| US-20110151258-A1 | PREPARATION OF RANOLAZINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-06-23 | — | — | US | disclosed |
| US-20110151258-A1 | PREPARATION OF RANOLAZINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-06-23 | — | — | US | disclosed |
| US-7906667-B2 | Method for producing optically active alcohol compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-03-15 | — | — | US | disclosed |
| US-20100234629-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-09-16 | — | — | US | disclosed |
| WO-2010025370-A2 | PREPARATION OF RANOLAZINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-03-04 | — | — | WO | disclosed |
| EP-1982973-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-10-22 | — | — | EP | disclosed |
| EP-0649402-A1 | PRO-DRUG CAPABLE OF RELEASING AN OXAZOLIDINONE AND, IF NEED BE, AN ACETAMIDOPHENOL | UNIVERSITE PAUL SABATIER (TOULOUSE III) (FR) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994001395-A1 | PRO-DRUG CAPABLE OF RELEASING AN OXAZOLIDINONE AND, IF NEED BE, AN ACETAMIDOPHENOL | UNIVERSITE PAUL SABATIER TOULOUSE III (FR) | 1994-01-20 | — | — | WO | disclosed |
| EP-0143381-B1 | BIPHENYLYLALKANOIC ACID DERIVATIVES, METHODS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREFROM | Dr. L. ZAMBELETTI S.p.A. (IT) | 1988-03-09 | — | — | EP | disclosed |
| US-4570013-A | ANTIPYRETIC, ANALGESIC, ANTIINFLAMMATORY AGENTS; METHOXYPHENOXYPROPANOL ESTERS | DR. L. ZAMBELETTI S.P.A. (IT) | 1986-02-11 | — | — | US | disclosed |
| EP-0143381-A2 | Biphenylylalkanoic acid derivatives, methods of preparation and pharmaceutical compositions therefrom | Dr. L. ZAMBELETTI S.p.A. (IT) | 1985-06-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090475-A1 | Process for the Preparation of Ranolazine | RANBP1, RANBP2, RAN | LMNA 319/4885CYP1A2 21/4885AGTR1 370/4885 |
| US-20100234629-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND | ADH1A, ADH1C, ADH5 | LMNA 3091/4885CYP1A2 263/4885AGTR1 604/4885 |
| US-20110151258-A1 | PREPARATION OF RANOLAZINE | RANBP1, RAN, ACHE | LMNA 348/4885CYP1A2 52/4885AGTR1 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.