SCHEMBL1496916

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496862	0.90	HTR5A (0.40)	HIF1AHDAC1CKS1BSKP1SKP2
	SCHEMBL1496860	0.89	ROCK2 (0.38)	HDAC1RAF1HTR5APDCD1CD274
	SCHEMBL1497043	0.88	HIF1A (0.42)	HIF1AHDAC1CKS1BSKP1SKP2
	SCHEMBL1496875	0.88	HTR5A (0.39)	HDAC1CKS1BSKP1SKP2HTR5A
	SCHEMBL1496843	0.87	KMT2A (0.40)	HDAC1RAF1ROCK1
	SCHEMBL7999036	0.87	HIF1A (0.45)	HIF1AHDAC1ALDH1A1KDM4ENPC1
	SCHEMBL1497447	0.87	HDAC1 (0.35)	HDAC1CKS1BSKP1SKP2RAF1
	SCHEMBL1497081	0.87	ADAM17 (0.35)	CKS1BSKP1SKP2ALDH1A1KDM4E
	SCHEMBL1496893	0.86	POLB (0.37)	HDAC1RAF1HTR5APDCD1CD274
	SCHEMBL1496892	0.86	CTSK (0.38)	HIF1AHDAC1CKS1BSKP1SKP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.