Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10476400 | 0.89 | KDM4E (0.37) | RAB9ASMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL1497020 | 0.85 | RAB9A (0.36) | RAB9ASMN1; SMN2KMT2AKDM4ECYP1A2 | |
| SCHEMBL1497137 | 0.80 | HDAC3 (0.39) | KMT2AKDM4EALDH1A1CYP1A2HDAC1 | |
| SCHEMBL1496898 | 0.80 | HDAC3 (0.38) | KMT2AKDM4EALDH1A1HSD17B10HDAC1 | |
| SCHEMBL1496975 | 0.79 | ALDH1A1 (0.41) | RAB9ASMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL1483181 | 0.79 | UTS2R (0.47) | KMT2AHIF1A | |
| SCHEMBL1497166 | 0.78 | ALDH1A1 (0.41) | KMT2AKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL1497005 | 0.78 | UTS2R (0.42) | KMT2AHDAC1HIF1AEPHX2 | |
| SCHEMBL1497209 | 0.78 | ALDH1A1 (0.41) | KMT2AKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL1482240 | 0.77 | ALDH1A1 (0.40) | KMT2AKDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |