Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496942 | 0.88 | THRB (0.35) | RAB9ASMN1; SMN2THRBMCHR2MCHR1 | |
| SCHEMBL1496978 | 0.85 | RAB9A (0.39) | RAB9ASMN1; SMN2MCHR2MCHR1DRD2 | |
| SCHEMBL1496935 | 0.80 | UTS2R (0.38) | CYP1A2 | |
| SCHEMBL1496936 | 0.80 | CYP1A2 (0.38) | CYP1A2 | |
| SCHEMBL1497031 | 0.80 | AKT1 (0.35) | CYP1A2 | |
| SCHEMBL1482305 | 0.77 | UTS2R (0.43) | — | |
| SCHEMBL1497015 | 0.77 | ALDH1A1 (0.36) | RAB9ASMN1; SMN2THRBDRD2KMT2A | |
| SCHEMBL1497095 | 0.77 | AKT1 (0.35) | SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL1497007 | 0.76 | ROCK2 (0.37) | SMN1; SMN2 | |
| SCHEMBL1482712 | 0.76 | UTS2R (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |