SCHEMBL1506429

SCHEMBL1506429

C=Cc1ccc(Br)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
TDP1 Q9NUW8 2/20 0.40
TP53 P04637 1/20 0.40
TSHR P16473 1/20 0.39
KDM1A O60341 3/20 0.37
KCNH2 Q12809 2/20 0.37
KDM1B Q8NB78 1/20 0.37
NFE2L2 Q16236 3/20 0.35
TRPA1 O75762 1/20 0.34
VCP P55072 1/20 0.34
MGAM O43451 1/20 0.34
GAA P10253 1/20 0.34
SI P14410 1/20 0.34
MGAM2 Q2M2H8 1/20 0.34
HDAC8 Q9BY41 1/20 0.33
RCOR1 Q9UKL0 1/20 0.33
KIF11 P52732 1/20 0.33
MAPT P10636 1/20 0.31
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29620495 1.00 ALDH1A1 (0.43) ALDH1A1TDP1TP53TSHRKDM1A
SCHEMBL5674421 0.82 VCP (0.50) ALDH1A1TDP1TP53TSHRNFE2L2
SCHEMBL31335437 0.79 NFE2L2 (0.39) KDM1AKCNH2KDM1BNFE2L2VCP
SCHEMBL29662132 0.78 NFE2L2 (0.50) ALDH1A1TDP1TP53TSHRNFE2L2
SCHEMBL2788648 0.78 ALDH1A1 (0.50) ALDH1A1TDP1TP53TSHRTRPA1
SCHEMBL248639 0.78 NFE2L2 (0.50) ALDH1A1TDP1TP53TSHRNFE2L2
SCHEMBL361060 0.77 ALDH1A1 (0.50) ALDH1A1TDP1TSHRKDM1AKCNH2
SCHEMBL16960237 0.77 KDM1A (0.37) KDM1AKCNH2KDM1BNFE2L2TRPA1
SCHEMBL28239186 0.77 KDM1A (0.37) ALDH1A1KDM1AKCNH2KDM1BNFE2L2
SCHEMBL11725687 0.74 ALDH1A1 (0.46) ALDH1A1TDP1TP53TSHRKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12404283-B2 c-MYC mRNA translation modulators and uses thereof in the treatment of cancer ANIMA BIOTECH INC. (US) 2025-09-02 US disclosed
EP-4547672-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2025-05-07 EP disclosed
US-20250129100-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-04-24 US disclosed
CN-119233976-A Modulators of c-MYC mRNA translation and their use in the treatment of cancer 艾尼莫生物科技公司 2024-12-31 CN disclosed
WO-2024010762-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 WO disclosed
WO-2024010762-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 WO disclosed
EP-3746444-B1 CYCLOALKYL SUBSTITUTED PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST RSV JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) 2023-09-27 EP disclosed
EP-3746444-B1 CYCLOALKYL SUBSTITUTED PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST RSV JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) 2023-09-27 EP disclosed
US-11661397-B2 1,4-disubstituted imidazole derivative Sumitomo Pharma Co., Ltd. (JP) 2023-05-30 US disclosed
US-11491157-B2 Cycloalkyl substituted pyrazolopyrimidines having activity against RSV Janssen Sciences Ireland Unlimited Company Co Cork, IE (IE) 2022-11-08 US disclosed
US-20170166552-A1 1,4-DISUBSTITUTED IMIDAZOLE DERIVATIVE Sumitomo Pharma Co., Ltd. (JP) 2017-06-15 US disclosed
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed
WO-2011161262-A1 EVAPORABLE ORGANICALLY SEMICONDUCTIVE MATERIAL AND USE THEREOF IN AN OPTOELECTRONIC COMPONENT HELIATEK GMBH (DE) 2011-12-29 WO disclosed
EP-1888523-B1 CYCLOBUTYL AMINE DERIVATIVES ABBOTT LAB (US) 2011-10-26 EP disclosed
EP-2298734-A2 Cyclobutyl amine derivatives Abbott Laboratories (US) 2011-03-23 EP disclosed
US-20090227593-A1 CYCLOBUTYL AMINE DERIVATIVES ABBOTT LABORATORIES (US) 2009-09-10 US disclosed
US-7553964-B2 Cyclobutyl amine derivatives ABBOTT LABORATORIES (US) 2009-06-30 US disclosed
EP-1888523-A2 CYCLOBUTYL AMINE DERIVATIVES Abbott Laboratories (US) 2008-02-20 EP disclosed
US-20070078133-A1 Cyclobutyl amine derivatives ABBVIE INC. 2007-04-05 US disclosed
WO-2006132914-A2 CYCLOBUTYL AMINE DERIVATIVES ABBOTT LABORATORIES (US) 2006-12-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170166552-A1 1,4-DISUBSTITUTED IMIDAZOLE DERIVATIVE NR4A3, NR0B1, NR2C2 ALDH1A1 278/4885TDP1 4690/4885TP53 247/4885
US-20250129100-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 ALDH1A1 4445/4885TDP1 3333/4885TP53 96/4885
US-11491157-B2 Cycloalkyl substituted pyrazolopyrimidines having activity against RSV ACE, ACE2, PTBP1 ALDH1A1 1750/4885TDP1 3004/4885TP53 3251/4885
US-20090227593-A1 CYCLOBUTYL AMINE DERIVATIVES HRH2, HRH4, HRH3 ALDH1A1 1245/4885TDP1 4575/4885TP53 4762/4885
US-12404283-B2 c-MYC mRNA translation modulators and uses thereof in the treatment of cancer MYC, MYCBP, MYCBP2 ALDH1A1 4445/4885TDP1 3333/4885TP53 96/4885
US-11661397-B2 1,4-disubstituted imidazole derivative NR4A3, NR0B1, NR2C2 ALDH1A1 278/4885TDP1 4690/4885TP53 247/4885
US-20070078133-A1 Cyclobutyl amine derivatives HRH2, HRH4, HRH3 ALDH1A1 1245/4885TDP1 4575/4885TP53 4762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.