Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996952 | 0.88 | MAOB (0.47) | SLC6A4SLC6A3SLC6A2POLBALDH1A1 | |
| SCHEMBL15065354 | 0.84 | LMNA (0.43) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL872275 | 0.83 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL15065680 | 0.82 | LMNA (0.42) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL878028 | 0.81 | SLC6A2 (0.54) | SLC6A4SLC6A3SLC6A2KMT2AALDH1A1 | |
| SCHEMBL5086480 | 0.81 | SLC6A3 (0.59) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL15065638 | 0.80 | CASP1 (0.49) | SLC6A4SLC6A3SLC6A2KMT2AALDH1A1 | |
| SCHEMBL871941 | 0.79 | SLC6A3 (0.53) | SLC6A4SLC6A3SLC6A2ALDH1A1 | |
| SCHEMBL871578 | 0.79 | SLC6A3 (0.53) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8606048 | 0.79 | SLC6A3 (0.53) | SLC6A4SLC6A3SLC6A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797870-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES | Reviva Pharmaceuticals, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013102195-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES | REVIVA PHARMACEUTICALS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |