Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL10437676 | 1.00 | — | — | |
| Tromethamine SCHEMBL1526047 | 0.96 | — | — | |
| Tromethamine SCHEMBL11131573 | 0.96 | — | — | |
| Tromethamine SCHEMBL975 | 0.95 | — | — | |
| Tromethamine SCHEMBL17484 | 0.95 | MEN1 (1.00) | — | |
| Tromethamine SCHEMBL3696191 | 0.95 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.91 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL6063594 | 0.91 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.91 | — | — | |
| Tromethamine SCHEMBL445853 | 0.91 | MEN1 (0.91) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203001-B1 | TRIS(OXALATO)PHOSPHATES, METHOD FOR THEIR PREPARATION AND THEIR USE | CHEMETALL GMBH (DE) | 2003-03-05 | — | — | EP | claimed |
| US-20210338527-A1 | PRESERVATIVE REMOVAL FROM EYE DROPS CONTAINING HYDROPHILIC DRUGS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2021-11-04 | — | — | US | disclosed |
| US-11033457-B2 | Preservative removal from eye drops containing hydrophilic drugs | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| EP-3687461-A1 | PRESERVATIVE REMOVAL FROM EYE DROPS CONTAINING HYDROPHILIC DRUGS | University of Florida Research Foundation, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| US-20190269575-A1 | PRESERVATIVE REMOVAL FROM EYE DROPS CONTAINING HYDROPHILIC DRUGS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2019-09-05 | — | — | US | disclosed |
| EP-2899199-B1 | CELL PENETRATING PEPTIDE, CONJUGATE COMPRISING SAME, AND COMPOSITION COMPRISING CONJUGATE | GEMVAX & KAEL CO LTD (KR) | 2019-07-03 | — | — | EP | disclosed |
| WO-2019060846-A1 | PRESERVATIVE REMOVAL FROM EYE DROPS CONTAINING HYDROPHILIC DRUGS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2019-03-28 | — | — | WO | disclosed |
| EP-2899199-A1 | CELL PENETRATING PEPTIDE, CONJUGATE COMPRISING SAME, AND COMPOSITION COMPRISING CONJUGATE | Gemvax & Kael Co., Ltd. (KR) | 2015-07-29 | — | — | EP | disclosed |
| EP-0030092-B1 | GUANIDINE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-02-06 | — | — | EP | disclosed |
| EP-0030503-A1 | Buffer overcoat for CO2 ion-selective electrodes | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1981-06-17 | — | — | EP | disclosed |