Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 9/20 | 0.61 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.61 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GHSR | Q92847 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313834 | 0.86 | ALOX12 (0.54) | GPR27AVPR2SNCAKMT2A | |
| SCHEMBL15313824 | 0.81 | BCL2 (0.68) | GPR27AVPR2NAMPTGHSRMAPT | |
| SCHEMBL15313831 | 0.80 | GPR27 (0.61) | GPR27AVPR2MEN1KMT2A | |
| SCHEMBL15705234 | 0.79 | IDO1 (0.76) | MAPK1MAPTMEN1KMT2A | |
| SCHEMBL15313827 | 0.78 | BCL2 (0.64) | GPR27AVPR2NAMPTMAPT | |
| SCHEMBL15313840 | 0.77 | FADS1 (0.49) | GPR27MEN1KMT2A | |
| SCHEMBL12197847 | 0.76 | GRM4 (0.76) | GPR27AVPR2NAMPTMAPK1MAPT | |
| SCHEMBL1592806 | 0.76 | LMNA (0.60) | MAPK1MAPTMEN1KMT2A | |
| SCHEMBL18027773 | 0.76 | NPC1 (0.63) | MAPTMEN1KMT2A | |
| SCHEMBL15313835 | 0.76 | CA12 (0.51) | GPR27AVPR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |