Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313875 | 0.81 | MAOA (0.47) | MAOAMAPTPOLBHDAC1KMT2A | |
| SCHEMBL15313898 | 0.81 | MAOA (0.46) | MAOAMAPTKMT2AALDH1A1LMNA | |
| SCHEMBL15313899 | 0.73 | BCL2 (0.67) | MAOAMAPTKMT2AALDH1A1LMNA | |
| SCHEMBL15313868 | 0.72 | BCL2L1 (0.61) | MAPTPOLBTBK1HDAC1KMT2A | |
| SCHEMBL13576567 | 0.70 | MEN1 (0.63) | MAOAHDAC1KMT2ARXFP1HDAC8 | |
| SCHEMBL15313887 | 0.69 | BCL2 (0.56) | MAOAMAPTKMT2AALDH1A1LMNA | |
| SCHEMBL4869345 | 0.66 | CA12 (0.68) | MAOAMAPTPOLBHDAC1KMT2A | |
| SCHEMBL15025442 | 0.63 | CA1 (0.60) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL15313879 | 0.62 | PTPRC (0.53) | MAOAMAPTPOLBKMT2AALDH1A1 | |
| SCHEMBL10972005 | 0.62 | MAOA (1.00) | MAOAMAPTKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |