Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353065 | 0.93 | MAPT (0.51) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL15319957 | 0.92 | MAPT (0.66) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL8070173 | 0.91 | HCAR3 (0.55) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL4444325 | 0.91 | HCAR3 (0.54) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL29848413 | 0.91 | HCAR3 (0.54) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL3091619 | 0.89 | ALDH1A1 (0.49) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL19245322 | 0.86 | ALOX15 (0.52) | MAPTALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL22382467 | 0.85 | KMT2A (0.60) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL3094959 | 0.85 | ALDH1A1 (0.55) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL15321361 | 0.85 | HCAR3 (0.68) | MAPTALDH1A1POLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597381-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190135782-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-05-09 | — | — | US | disclosed |
| US-10233171-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-03-19 | — | — | US | disclosed |
| US-20170233370-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-17 | — | — | US | disclosed |
| US-9580398-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150079035-A1 | Compounds, Compositions, and Methods For Modulating Ferroptosis and Treating Excitotoxic Disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-03-19 | — | — | US | disclosed |
| WO-2013152039-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597381-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | AIFM2, GPX1, GPX4 | MAPT 88/4885ALDH1A1 1311/4885POLB 4782/4885 |
| US-20150079035-A1 | Compounds, Compositions, and Methods For Modulating Ferroptosis and Treating Excitotoxic Disorders | AIFM2, GPX1, GPX4 | MAPT 157/4885ALDH1A1 897/4885POLB 4651/4885 |
| US-20170233370-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, GPX4 | MAPT 88/4885ALDH1A1 1311/4885POLB 4782/4885 |
| US-10233171-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | AIFM2, GPX1, GPX4 | MAPT 88/4885ALDH1A1 1311/4885POLB 4782/4885 |
| US-20190135782-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, GPX4 | MAPT 88/4885ALDH1A1 1311/4885POLB 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.