Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 20/20 | 0.53 |
| ▸ | GABRD | O14764 | 20/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 20/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 20/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 20/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 20/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 20/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 20/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 20/20 | 0.53 |
| ▸ | GABRE | P78334 | 20/20 | 0.53 |
| ▸ | GABRA6 | Q16445 | 20/20 | 0.53 |
| ▸ | GABRG1 | Q8N1C3 | 20/20 | 0.53 |
| ▸ | GABRG3 | Q99928 | 20/20 | 0.53 |
| ▸ | GABRQ | Q9UN88 | 20/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fipronil SCHEMBL15088 | 0.93 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fipronil SCHEMBL29397350 | 0.93 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fipronil SCHEMBL2469515 | 0.93 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fipronil SCHEMBL44222 | 0.93 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fipronil SCHEMBL7171206 | 0.93 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fipronil SCHEMBL3351877 | 0.92 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL14094912 | 0.89 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2835863 | 0.87 | GABRB3 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15329430 | 0.87 | GABRB3 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8790587 | 0.87 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104334534-B | Improved process for preparing 1-aryl-5-alkylpyrazole compounds | 勃林格殷格翰动物保健美国公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-3184510-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3184510-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3184510-A1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | Merial, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-3184510-A1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | Merial, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2852577-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2852577-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2017-03-01 | — | — | EP | disclosed |
| US-9273007-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273007-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273007-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2015-03-12 | — | — | US | disclosed |
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2015-03-12 | — | — | US | disclosed |
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2015-03-12 | — | — | US | disclosed |
| US-8937185-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL LIMITED (US) | 2015-01-20 | — | — | US | disclosed |
| US-8937185-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL LIMITED (US) | 2015-01-20 | — | — | US | disclosed |
| US-8937185-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL LIMITED (US) | 2015-01-20 | — | — | US | disclosed |
| US-20130281710-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130281710-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130281710-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2013-10-24 | — | — | US | disclosed |
| WO-2013159094-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2013-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | SULT1A1, CYP1B1, CYP2F1 | GABRP 1164/4885GABRD 2354/4885GABRA1 729/4885 |
| US-20130281710-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | SULT1A1, CYP1B1, CYP2F1 | GABRP 1164/4885GABRD 2354/4885GABRA1 729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.