Sugi Predict

Sugi Predict / Compounds / SCHEMBL15329430

SCHEMBL15329430

SCHEMBL15329430

N#Cc1nn(-c2c(F)cc(C(F)(F)F)cc2Cl)c(Br)c1[S+]([O-])C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRB3 P28472 19/20 0.43
▸ GABRA2 P47869 17/20 0.43
▸ GABRB2 P47870 17/20 0.43
▸ GABRP O00591 16/20 0.43
▸ GABRD O14764 16/20 0.43
▸ GABRA1 P14867 16/20 0.43
▸ GABRB1 P18505 16/20 0.43
▸ GABRG2 P18507 16/20 0.43
▸ GABRA5 P31644 16/20 0.43
▸ GABRA3 P34903 16/20 0.43
▸ GABRA4 P48169 16/20 0.43
▸ GABRE P78334 16/20 0.43
▸ GABRA6 Q16445 16/20 0.43
▸ GABRG1 Q8N1C3 16/20 0.43
▸ GABRG3 Q99928 16/20 0.43
▸ GABRQ Q9UN88 16/20 0.43
▸ NR1I2 O75469 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ CYP3A4 P08684 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6055883 0.93 GABRB3 (0.48) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL15329374 0.87 GABRP (0.53) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL2835863 0.87 GABRB3 (0.43) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL9175007 0.87 GABRB3 (0.48) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL9167192 0.86 GABRB3 (0.47) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL2841665 0.85 GABRB3 (0.41) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL5201997 0.83 GABRB3 (0.49) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL2492625 0.81 GABRB3 (0.43) GABRB3GABRA2GABRB2GABRPGABRD
Fipronil SCHEMBL44222 0.80 GABRP (0.59) GABRB3GABRA2GABRB2GABRPGABRD
Fipronil SCHEMBL15088 0.80 GABRP (0.59) GABRB3GABRA2GABRB2GABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104334534-B Improved process for preparing 1-aryl-5-alkylpyrazole compounds 勃林格殷格翰动物保健美国公司 2020-01-10 — — CN disclosed
EP-3184510-B1 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL INC (US) 2019-06-12 — — EP disclosed
EP-3184510-B1 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL INC (US) 2019-06-12 — — EP disclosed
EP-3184510-A1 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS Merial, Inc. (US) 2017-06-28 — — EP disclosed
EP-3184510-A1 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS Merial, Inc. (US) 2017-06-28 — — EP disclosed
EP-2852577-B1 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL INC (US) 2017-03-01 — — EP disclosed
EP-2852577-B1 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL INC (US) 2017-03-01 — — EP disclosed
US-9273007-B2 Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds MERIAL, INC. (US) 2016-03-01 — — US disclosed
US-9273007-B2 Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds MERIAL, INC. (US) 2016-03-01 — — US disclosed
US-9273007-B2 Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds MERIAL, INC. (US) 2016-03-01 — — US disclosed
US-20150073153-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2015-03-12 — — US disclosed
US-20150073153-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2015-03-12 — — US disclosed
US-20150073153-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2015-03-12 — — US disclosed
US-8937185-B2 Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds MERIAL LIMITED (US) 2015-01-20 — — US disclosed
US-8937185-B2 Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds MERIAL LIMITED (US) 2015-01-20 — — US disclosed
US-8937185-B2 Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds MERIAL LIMITED (US) 2015-01-20 — — US disclosed
WO-2013159094-A2 IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2013-10-24 — — WO disclosed
US-20130281710-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2013-10-24 — — US disclosed
US-20130281710-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2013-10-24 — — US disclosed
US-20130281710-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS MERIAL LIMITED (US) 2013-10-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150073153-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS SULT1A1, CYP1B1, CYP2F1 GABRB3 829/4885GABRA2 1401/4885GABRB2 1011/4885
US-20130281710-A1 PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS SULT1A1, CYP1B1, CYP2F1 GABRB3 829/4885GABRA2 1401/4885GABRB2 1011/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.