Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL36655 | 0.73 | CAD (0.44) | ALDH1A1MGAMGAASIMGAM2 | |
| SCHEMBL11513443 | 0.68 | MMP1 (0.48) | ALDH1A1ACACBCHRNB2CHRNB4CHRNA4 | |
| SCHEMBL7695367 | 0.68 | TGFBR1 (0.46) | ALDH1A1MGAMGAASIMGAM2 | |
| SCHEMBL7698482 | 0.68 | TSHR (0.50) | ALDH1A1ACACBMGAMGAASI | |
| SCHEMBL3895254 | 0.67 | ALDH1A1 (0.37) | ALDH1A1CHRNB2CHRNB4CHRNA4MGAM | |
| SCHEMBL27796677 | 0.67 | LMNA (0.32) | — | |
| SCHEMBL5353472 | 0.67 | ALDH1A1 (0.43) | ALDH1A1ACACBCHRNB2CHRNB4CHRNA4 | |
| SCHEMBL10850954 | 0.67 | ALDH1A1 (0.43) | ALDH1A1ACACBCHRNB2CHRNB4CHRNA4 | |
| SCHEMBL2625556 | 0.66 | — | — | |
| SCHEMBL21680740 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349643-A1 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS | FIVE PRIME THERAPEUTICS, INC. (US) | 2017-12-07 | — | — | US | disclosed |
| US-20160096876-A1 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS | FIVE PRIME THERAPEUTICS INC (US) | 2016-04-07 | — | — | US | disclosed |
| US-20140140995-A1 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS | FIVE PRIME THERAPEUTICS, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-8580936-B2 | Polynucleotides encoding FGFR1-IIIc ECD fusion proteins | FIVE PRIME THERAPEUTICS, INC. (US) | 2013-11-12 | — | — | US | disclosed |