Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542839 | 0.80 | TRPM8 (0.40) | P2RX4TRPM8KCNA5ALDH1A1HPGD | |
| SCHEMBL4301160 | 0.78 | TRPM8 (0.46) | P2RX4TRPM8KCNA5ALDH1A1HPGD | |
| SCHEMBL27466763 | 0.75 | ALDH1A1 (0.46) | P2RX4TRPM8KCNA5ALDH1A1HPGD | |
| SCHEMBL16946017 | 0.74 | TRPV1 (0.55) | TRPM8KCNA5TRPV1EPHX1 | |
| SCHEMBL30835092 | 0.74 | TRPM8 (0.50) | P2RX4TRPM8KCNA5ALDH1A1HPGD | |
| SCHEMBL11421939 | 0.73 | TRPM8 (0.45) | TRPM8KCNA5ALDH1A1HPGDLMNA | |
| SCHEMBL10949151 | 0.71 | KCNA5 (0.49) | P2RX4TRPM8KCNA5ALDH1A1HPGD | |
| SCHEMBL7041471 | 0.70 | KCNA5 (0.49) | P2RX4TRPM8KCNA5ALDH1A1HPGD | |
| SCHEMBL5718187 | 0.69 | EPHX1 (0.51) | TRPM8KCNA5ALDH1A1HPGDLMNA | |
| Menthol SCHEMBL29264508 | 0.69 | TRPM8 (0.70) | P2RX4TRPM8KCNA5ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515895-B1 | ORAL CARE COMPOSITIONS AND METHODS | COLGATE PALMOLIVE CO (US) | 2018-02-14 | — | — | EP | claimed |
| US-20150086490-A1 | ORAL CARE COMPOSITIONS AND METHODS | COLGATE PALMOLIVE CO (US) | 2015-03-26 | — | — | US | claimed |
| US-8911715-B2 | L-menthyl-N-(2-hydroxyphenyl)carbamate | SYMRISE AG (DE) | 2014-12-16 | — | — | US | claimed |
| US-20110129432-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | SYMRISE AG (DE) | 2011-06-02 | — | — | US | claimed |
| EP-2307357-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | Symrise AG (DE) | 2011-04-13 | — | — | EP | claimed |
| WO-2009144179-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | SYMRISE GMBH & CO. KG (DE) | 2009-12-03 | — | — | WO | claimed |
| US-20150086490-A1 | ORAL CARE COMPOSITIONS AND METHODS | COLGATE PALMOLIVE CO (US) | 2015-03-26 | — | — | US | disclosed |
| US-8911715-B2 | L-menthyl-N-(2-hydroxyphenyl)carbamate | SYMRISE AG (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8911715-B2 | L-menthyl-N-(2-hydroxyphenyl)carbamate | SYMRISE AG (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8911715-B2 | L-menthyl-N-(2-hydroxyphenyl)carbamate | SYMRISE AG (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20110129432-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | SYMRISE AG (DE) | 2011-06-02 | — | — | US | disclosed |
| US-20110129432-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | SYMRISE AG (DE) | 2011-06-02 | — | — | US | disclosed |
| EP-2307357-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | Symrise AG (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-2307357-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | Symrise AG (DE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009144179-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | SYMRISE GMBH & CO. KG (DE) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009144179-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | SYMRISE GMBH & CO. KG (DE) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129432-A1 | L-MENTHYL-N-(2-HYDROXYPHENYL)CARBAMATE | CRAT, LANCL1, ACAT1 | P2RX4 1577/4885TRPM8 895/4885KCNA5 2305/4885 |
| US-20150086490-A1 | ORAL CARE COMPOSITIONS AND METHODS | MMP13, MMP9, MMP3 | P2RX4 4374/4885TRPM8 4354/4885KCNA5 4721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.