SCHEMBL15469208

SCHEMBL15469208

[N-]=[N+]=NCc1cnc(C[C@H](N)C(=O)O)s1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 3/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ SLC1A3 P43003 1/20 0.34
▸ PKM P14618 2/20 0.33
▸ ALPI P09923 1/20 0.33
▸ PTGS1 P23219 1/20 0.33
▸ XIAP P98170 1/20 0.33
▸ GRM8 O00222 1/20 0.33
▸ GRM4 Q14833 1/20 0.33
▸ GRIA1 P42261 3/20 0.33
▸ GRIA3 P42263 3/20 0.33
▸ GRIA2 P42262 3/20 0.33
▸ GRIA4 P48058 2/20 0.33
▸ GRIK1 P39086 1/20 0.32
▸ GRIK2 Q13002 1/20 0.32
▸ GRIK3 Q13003 1/20 0.32
▸ GRIK4 Q16099 1/20 0.32
▸ GRIK5 Q16478 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16644964 0.77 HDAC6 (0.37) —
SCHEMBL24823223 0.75 LOXL2 (0.36) —
SCHEMBL15469215 0.74 SLC7A5 (0.35) SLC7A5HSD17B10CYP3A4SLC1A3PKM
SCHEMBL15469243 0.74 HSD17B10 (0.34) SLC7A5HSD17B10CYP3A4SLC1A3PKM
SCHEMBL17080194 0.72 KAT2B (0.31) —
SCHEMBL15469228 0.72 SLC7A5 (0.41) SLC7A5HSD17B10CYP3A4PKMALPI
SCHEMBL16561852 0.72 GRM8 (0.42) SLC7A5HSD17B10CYP3A4SLC1A3PKM
SCHEMBL25221972 0.71 SLC7A5 (0.41) SLC7A5HSD17B10CYP3A4SLC1A3PKM
SCHEMBL15469205 0.71 CYP1A2 (0.37) SLC7A5HSD17B10CYP3A4SLC1A3PKM
SCHEMBL15511517 0.71 SLC7A5 (0.41) SLC7A5HSD17B10CYP3A4PKMALPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-01-25 — — US disclosed
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-01-25 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates SUTRO BIOPHARMA, INC. (US) 2023-07-25 — — US disclosed
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates SUTRO BIOPHARMA, INC. (US) 2023-07-25 — — US disclosed
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-11548852-B2 Modified amino acids SUTRO BIOPHARMA, INC. (US) 2023-01-10 — — US disclosed
EP-4074728-A1 MODIFIED PEPTIDES COMPRISING AN AZIDO GROUP Sutro Biopharma, Inc. (US) 2022-10-19 — — EP disclosed
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2016-09-01 — — US disclosed
WO-2015054658-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2015-04-16 — — WO disclosed
WO-2015006555-A2 ANTIBODIES COMPRISING MULTIPLE SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2015-01-15 — — WO disclosed
US-20140066598-A1 Modified Amino Acids SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — US disclosed
US-20140066598-A1 Modified Amino Acids SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — US disclosed
WO-2014036492-A1 MODIFIED AMINO ACIDS COMPRISING AN AZIDO GROUP SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — WO disclosed
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use SUTRO BIOPHARMA, INC. 2014-02-20 — — US disclosed
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use SUTRO BIOPHARMA, INC. 2014-02-20 — — US disclosed
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2014-02-13 — — US disclosed
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2014-02-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use FCGR2A, FCGR3B, FCGR1A SLC7A5 888/4885HSD17B10 4076/4885CYP3A4 3961/4885
US-11548852-B2 Modified amino acids PTMS, DNPEP, ANPEP SLC7A5 80/4885HSD17B10 4458/4885CYP3A4 4714/4885
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES CD74, CD63, CD99 SLC7A5 2691/4885HSD17B10 3635/4885CYP3A4 2755/4885
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates CD74, CD63, CD99 SLC7A5 2703/4885HSD17B10 3414/4885CYP3A4 2613/4885
US-20140066598-A1 Modified Amino Acids PTMS, DNPEP, ANPEP SLC7A5 80/4885HSD17B10 4458/4885CYP3A4 4714/4885
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof FCGR1A, FCGR2A, FCGRT SLC7A5 3848/4885HSD17B10 3096/4885CYP3A4 2357/4885
US-20230139442-A1 MODIFIED AMINO ACIDS PTMS, DNPEP, ANPEP SLC7A5 80/4885HSD17B10 4458/4885CYP3A4 4714/4885
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE DNPEP, SLC1A5, AADAT SLC7A5 14/4885HSD17B10 3807/4885CYP3A4 3547/4885
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE DNPEP, LNPEP, ANPEP SLC7A5 310/4885HSD17B10 3529/4885CYP3A4 4840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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