Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795642 | 0.88 | CA1 (0.50) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL4775793 | 0.88 | CA1 (0.50) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL15538546 | 0.84 | RORC (0.36) | HPGDTSHRALDH1A1ALOX15HSD17B10 | |
| SCHEMBL16785950 | 0.80 | GABRA1 (0.52) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL6682827 | 0.80 | GABRA1 (0.63) | GABRA1GABRB1GABRB2CA1CA2 | |
| SCHEMBL15539638 | 0.80 | CA2 (0.33) | GABRA1GABRB1CA2THRATHRB | |
| SCHEMBL16788662 | 0.79 | CYP3A4 (0.34) | CA1CA2CYP3A4HPGDTSHR | |
| SCHEMBL21487350 | 0.76 | ADRB2 (0.33) | CYP3A4HPGDTSHRHIF1AALDH1A1 | |
| SCHEMBL16788668 | 0.75 | CYP2C19 (0.35) | GABRA1GABRB2CA1CA2CYP3A4 | |
| SCHEMBL15538671 | 0.73 | HMGCR (0.33) | CYP3A4HPGDTSHRHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | claimed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | claimed |
| WO-2013188716-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | claimed |
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | disclosed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | disclosed |
| WO-2013188716-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | PNMT, COMT, GABRE | GABRA1 75/4885GABRB1 37/4885GABRB2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.