Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15539232 | 0.84 | GABRA1 (0.44) | TSHRADRB2ALDH1A1GAAHPGD | |
| SCHEMBL15558445 | 0.77 | RORC (0.53) | RORCTSHRADRB2USP2ALDH1A1 | |
| SCHEMBL16788668 | 0.77 | CYP2C19 (0.35) | TSHRADRB2ALDH1A1HPGDALOX15 | |
| SCHEMBL15538671 | 0.75 | HMGCR (0.33) | TSHRADRB2ALDH1A1HPGDALOX15 | |
| SCHEMBL16788662 | 0.74 | CYP3A4 (0.34) | TSHRADRB2ALDH1A1HPGDALOX15 | |
| SCHEMBL7068142 | 0.74 | GABRA1 (0.50) | RORCTSHRUSP2ALDH1A1GAA | |
| SCHEMBL1795642 | 0.72 | CA1 (0.50) | TSHRUSP2ALDH1A1GAAHPGD | |
| SCHEMBL4775793 | 0.72 | CA1 (0.50) | TSHRUSP2ALDH1A1GAAHPGD | |
| SCHEMBL13920802 | 0.71 | ALDH1A1 (0.44) | RORCTSHRUSP2ALDH1A1GAA | |
| SCHEMBL21487350 | 0.71 | ADRB2 (0.33) | TSHRADRB2ALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | claimed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | claimed |
| WO-2013188716-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | claimed |
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | disclosed |
| WO-2013188716-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | PNMT, COMT, GABRE | RORC 335/4885TSHR 3125/4885ADRB2 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.