Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 6/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11953305 | 0.83 | ALDH1A1 (0.45) | GABRA2GABRB2CYP1A2GAAALDH1A1 | |
| SCHEMBL15545388 | 0.80 | TRPM8 (0.50) | CYP1A2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL221045 | 0.79 | ALDH1A1 (0.41) | GABRA2GABRB2CYP1A2GAAALDH1A1 | |
| SCHEMBL15545447 | 0.77 | KDM4E (0.50) | GABRA2GABRB2CYP1A2GAAALDH1A1 | |
| SCHEMBL4083192 | 0.76 | KDM4E (0.60) | GABRA2GABRB2GAAALDH1A1KDM4E | |
| SCHEMBL15546061 | 0.76 | GABRA2 (0.55) | GABRA2GABRB2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL12597336 | 0.76 | EGFR (0.50) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL5013542 | 0.75 | GABRA2 (0.54) | GABRA2GABRB2GAAALDH1A1HPGD | |
| SCHEMBL16416828 | 0.75 | KDM4E (0.48) | GABRA2GABRB2CYP1A2GAAALDH1A1 | |
| SCHEMBL5017019 | 0.74 | SMN1; SMN2 (0.51) | GABRA2GABRB2CYP1A2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| EP-2870164-B1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-14 | — | — | EP | disclosed |
| EP-2870164-B1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-14 | — | — | EP | disclosed |
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-18 | — | — | US | disclosed |
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-18 | — | — | US | disclosed |
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-18 | — | — | US | disclosed |
| EP-2870164-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014006130-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014006130-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-01-09 | — | — | WO | disclosed |
| EP-2682395-A1 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
| EP-2682395-A1 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SIGMAR1, TMEM97, ADRB2 | GABRA2 146/4885GABRB2 191/4885CYP1A2 371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.