Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16416828 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL15546232 | 0.77 | GABRA2 (0.56) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL15349666 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL1999180 | 0.76 | RXFP1 (0.45) | KDM4EALDH1A1HPGDMAPTRXFP1 | |
| SCHEMBL31210467 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL1572425 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL15188324 | 0.74 | BAZ2B (0.36) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL1500236 | 0.73 | KDM4E (0.64) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL11953305 | 0.73 | ALDH1A1 (0.45) | KDM4EALDH1A1POLBHPGDCYP1A2 | |
| SCHEMBL23534234 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1POLBHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260028334-A1 | N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER | WMT AG (DE) | 2026-01-29 | — | — | US | disclosed |
| EP-4504723-A1 | N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER | WMT AG (DE) | 2025-02-12 | — | — | EP | disclosed |
| CN-118974040-A | N- (3- (benzo [ B ] thiophen-2-amido) -phenyl) -2, 3-dihydrobenzo [ B ] [1,4] dioxin-6-amide derivatives and related compounds as lactic acid/ATP production inhibitors for the treatment of cancer | 威马特股份公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023194458-A1 | N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER | WMT AG (DE) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023194458-A1 | N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER | WMT AG (DE) | 2023-10-12 | — | — | WO | disclosed |
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| EP-2870164-B1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-14 | — | — | EP | disclosed |
| EP-2870164-B1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-14 | — | — | EP | disclosed |
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-18 | — | — | US | disclosed |
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-18 | — | — | US | disclosed |
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-18 | — | — | US | disclosed |
| EP-2870164-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014006130-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014006130-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-01-09 | — | — | WO | disclosed |
| EP-2682395-A1 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
| EP-2682395-A1 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166574-A1 | IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SIGMAR1, TMEM97, ADRB2 | KDM4E 4747/4885ALDH1A1 1060/4885POLB 2898/4885 |
| US-20260028334-A1 | N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LDHA, LDHB, SLC6A1 | KDM4E 3524/4885ALDH1A1 129/4885POLB 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.