Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375383 | 0.82 | MAPT (0.50) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL132456 | 0.78 | MAPT (0.41) | ALDH1A1MAPTKMT2AMEN1TP53 | |
| SCHEMBL6800997 | 0.77 | MAPT (0.41) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL2667242 | 0.77 | KMT2A (0.47) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL5362163 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MAPTKMT2APOLBTP53 | |
| SCHEMBL19444603 | 0.73 | ALDH1A1 (0.45) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL12323192 | 0.71 | POLB (0.54) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL11184712 | 0.71 | ALDH1A1 (0.72) | ALDH1A1KMT2APOLBMEN1SMN1; SMN2 | |
| SCHEMBL2606412 | 0.69 | S1PR3 (0.47) | KMT2AMEN1NPSR1KDM4ELMNA | |
| SCHEMBL20405434 | 0.68 | ALDH1A1 (0.61) | ALDH1A1KMT2APOLBMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020720-B1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX INC (US) | 2018-09-19 | — | — | EP | disclosed |
| US-20170333459-A1 | METHODS OF TREATING ORTHOPOX VIRUS INFECTIONS AND ASSOCIATED DISEASES | CHIMERIX, INC. | 2017-11-23 | — | — | US | disclosed |
| EP-2611818-B1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX INC (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-3020720-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | Chimerix, Inc. (US) | 2016-05-18 | — | — | EP | disclosed |
| US-9303051-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-11-19 | — | — | US | disclosed |
| US-20150141375-A1 | Methods of Treating Viral Associated Diseases | CHIMERIX, INC. | 2015-05-21 | — | — | US | disclosed |
| US-20140121186-A1 | Compounds, Compositions and Methods for Treating Ocular Conditions | CHIMERIX, INC. (US) | 2014-05-01 | — | — | US | disclosed |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8614200-B2 | Compounds, compositions and methods for treating ocular conditions | CHIMERIX, INC. (US) | 2013-12-24 | — | — | US | disclosed |
| US-20120164104-A1 | Composition and Methods of Treating Viral Infections and Viral Induced Tumors | CHIMERIX, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165295-A1 | Compounds, Compositions and Methods for Treating Ocular Conditions | CHIMERIX, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2462152-A1 | COMPOSITION AND METHODS OF TREATING VIRAL INFECTIONS AND VIRAL INDUCED TUMORS | Chimerix, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2012031045-A2 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20110263536-A1 | Methods of Treating Orthopox Virus Infections and Associated Diseases | CHIMERIX, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| WO-2011053812-A1 | METHODS OF TREATING VIRAL ASSOCIATED DISEASES | CHIMERIX, INC. (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011017253-A1 | COMPOSITION AND METHODS OF TREATING VIRAL INFECTIONS AND VIRAL INDUCED TUMORS | CHIMERIX, INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2011011519-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OCULAR CONDITIONS | CHIMERIX, INC. (US) | 2011-01-27 | — | — | WO | disclosed |
| US-5449528-A | Acid salt of guanidine derivative | HUELS AKTIENGESELLSCHAFT (DE) | 1995-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140121186-A1 | Compounds, Compositions and Methods for Treating Ocular Conditions | EYA3, EYA2, PDE6C | ALDH1A1 1123/4885MAPT 1084/4885KMT2A 3736/4885 |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | ALDH1A1 2151/4885MAPT 3413/4885KMT2A 2791/4885 |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | ALDH1A1 2151/4885MAPT 3413/4885KMT2A 2791/4885 |
| US-20120165295-A1 | Compounds, Compositions and Methods for Treating Ocular Conditions | EYA3, EYA2, PDE6C | ALDH1A1 1123/4885MAPT 1084/4885KMT2A 3736/4885 |
| US-20110263536-A1 | Methods of Treating Orthopox Virus Infections and Associated Diseases | OAT, PNPO, OTC | ALDH1A1 2374/4885MAPT 3066/4885KMT2A 3252/4885 |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PIK3CA, PNP | ALDH1A1 2151/4885MAPT 3413/4885KMT2A 2791/4885 |
| US-20170333459-A1 | METHODS OF TREATING ORTHOPOX VIRUS INFECTIONS AND ASSOCIATED DISEASES | OAT, PNPO, OTC | ALDH1A1 2374/4885MAPT 3066/4885KMT2A 3252/4885 |
| US-20150141375-A1 | Methods of Treating Viral Associated Diseases | HAVCR2, EIF2AK2, TSLP | ALDH1A1 1045/4885MAPT 2800/4885KMT2A 2392/4885 |
| US-20120164104-A1 | Composition and Methods of Treating Viral Infections and Viral Induced Tumors | HAVCR2, IRF3, CCL5 | ALDH1A1 2448/4885MAPT 2908/4885KMT2A 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.