SCHEMBL4375383

SCHEMBL4375383

CN(C(=O)N1CCOCC1)C1CCCCC1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
ABHD6 Q9BV23 2/20 0.46
LIPE Q05469 1/20 0.43
ALDH1A1 P00352 3/20 0.43
KMT2A Q03164 2/20 0.43
NPC1 O15118 1/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43
POLB P06746 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
PKM P14618 1/20 0.42
VNN1 O95497 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA9 Q16790 1/20 0.41
MMP13 P45452 1/20 0.41
MEN1 O00255 1/20 0.40
TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24518383 0.85 LIPE (0.44) LIPEALDH1A1KMT2AHTTPKM
SCHEMBL28019652 0.85 LIPE (0.44) LIPEALDH1A1KMT2AHTTPKM
SCHEMBL15551380 0.85 LIPE (0.44) LIPEALDH1A1KMT2AHTTPKM
SCHEMBL12349632 0.85 MAPT (0.49) MAPTALDH1A1KMT2ALMNAHTT
SCHEMBL1561258 0.83 MAPT (0.47) MAPTALDH1A1KMT2APOLBSMN1; SMN2
SCHEMBL155479 0.82 ALDH1A1 (0.45) MAPTALDH1A1KMT2ANPC1LMNA
SCHEMBL1561215 0.81 LMNA (0.49) LIPEALDH1A1NPC1LMNAHTT
SCHEMBL9469262 0.80 PDK1 (0.43) ABHD6LIPEALDH1A1NPC1LMNA
SCHEMBL31097151 0.80 HPGD (0.43) LIPEALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL30967383 0.79 CA2 (0.44) LIPEALDH1A1KMT2APKMCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2091925-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION OF SAME Boehringer Ingelheim International GmbH (DE) 2009-08-26 EP claimed
WO-2008055854-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION OF SAME BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-15 WO claimed
EP-2091925-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION OF SAME Boehringer Ingelheim International GmbH (DE) 2009-08-26 EP disclosed
WO-2008055854-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION OF SAME BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-15 WO disclosed