Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589904 | 0.80 | TP53 (0.34) | ALDH1A1HPGD | |
| SCHEMBL19431432 | 0.76 | L3MBTL1 (0.33) | ALDH1A1KDM4EGAA | |
| SCHEMBL15958850 | 0.74 | TRPV4 (0.38) | GABRA1GABRG2GABRB3ALDH1A1KDM4E | |
| SCHEMBL15322142 | 0.70 | AR (0.37) | ALDH1A1AR | |
| SCHEMBL26457742 | 0.69 | ALDH1A1 (0.35) | GABRA1GABRG2GABRB3ALDH1A1KDM4E | |
| SCHEMBL11852191 | 0.67 | GABRA1 (0.44) | GABRA1GABRG2GABRB3ALDH1A1HPGD | |
| SCHEMBL6416771 | 0.66 | ALDH1A1 (0.38) | GABRA1GABRG2GABRB3ALDH1A1KDM4E | |
| SCHEMBL410587 | 0.66 | TRPV4 (0.57) | GABRA1GABRG2GABRB3ALDH1A1KDM4E | |
| SCHEMBL27974294 | 0.66 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDAR | |
| SCHEMBL366053 | 0.66 | VCAM1 (0.48) | GABRA1GABRG2GABRB3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013149996-A9 | SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS | ALMIRALL, S.A. (ES) | 2014-02-20 | — | — | WO | disclosed |