Sugi Predict

Sugi Predict / Compounds / SCHEMBL15714872

SCHEMBL15714872

SCHEMBL15714872

COC(=O)c1cccc(N=[N+]=[N-])c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LOXL2 Q9Y4K0 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ CYP4F2 P78329 2/20 0.46
▸ CYP4A11 Q02928 2/20 0.46
▸ RAB9A P51151 4/20 0.46
▸ MAPT P10636 3/20 0.46
▸ CASP3 P42574 1/20 0.46
▸ SENP8 Q96LD8 1/20 0.46
▸ SENP7 Q9BQF6 1/20 0.46
▸ SENP6 Q9GZR1 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ GRIN2D O15399 1/20 0.46
▸ GRIN3B O60391 1/20 0.46
▸ GRIN1 Q05586 1/20 0.46
▸ GRIN2A Q12879 1/20 0.46
▸ GRIN2B Q13224 1/20 0.46
▸ GRIN2C Q14957 1/20 0.46
▸ GRIN3A Q8TCU5 1/20 0.46
▸ POLB P06746 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24041385 0.84 CA1 (0.48) TSHRRAB9AMAPTCASP3SENP8
SCHEMBL23723371 0.84 KDM4E (0.51) TSHRRAB9AMAPTCASP3SENP8
SCHEMBL16712672 0.83 CYP4F2 (0.49) TSHRCYP4F2CYP4A11RAB9AL3MBTL1
SCHEMBL13724974 0.81 ALDH1A1 (0.43) RAB9AMAPTALDH1A1NPC1MEN1
SCHEMBL69664 0.81 RAB9A (0.62) LOXL2TSHRCYP4F2CYP4A11RAB9A
SCHEMBL69663 0.81 RAB9A (0.62) LOXL2TSHRCYP4F2CYP4A11RAB9A
SCHEMBL19983030 0.81 HDAC8 (0.53) L3MBTL1POLBALDH1A1MEN1KMT2A
SCHEMBL13457142 0.80 RAB9A (0.56) TSHRRAB9AMAPTCASP3SENP8
SCHEMBL13653935 0.80 MAOB (0.48) RAB9AMAPTL3MBTL1POLBALDH1A1
SCHEMBL10160451 0.80 TSHR (0.53) LOXL2TSHRCYP4F2CYP4A11RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118406037-B Triazole derivative and preparation method and application thereof 四川师范大学 2025-02-25 — — CN disclosed
CN-118406037-A Triazole derivative and preparation method and application thereof 四川师范大学 2024-07-30 — — CN disclosed
EP-3817811-B1 TRIAZOLE BENZAMIDE DERIVATIVES AS GPR142 AGONISTS BOEHRINGER INGELHEIM INT (DE) 2024-04-03 — — EP disclosed
CN-112368049-B Triazole benzamide derivatives as GPR142 agonists 勃林格殷格翰国际有限公司 2024-03-29 — — CN disclosed
CN-109071468-B Heterocyclic compound and preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2022-09-02 — — CN disclosed
US-11179371-B2 Triazole benzamide derivatives as GPR142 agonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-11-23 — — US disclosed
EP-3817811-A1 TRIAZOLE BENZAMIDE DERIVATIVES AS GPR142 AGONISTS Boehringer Ingelheim International GmbH (DE) 2021-05-12 — — EP disclosed
CN-112368049-A Triazole benzamide derivatives as GPR142 agonists 勃林格殷格翰国际有限公司 2021-02-12 — — CN disclosed
CN-109369623-B Substituted 1,2,3 triazole diaryl pyrimidine derivative and preparation method and application thereof 山东大学 2020-04-21 — — CN disclosed
WO-2020007729-A1 TRIAZOLE BENZAMIDE DERIVATIVES AS GPR142 AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2020-01-09 — — WO disclosed
US-20020193367-A1 Dihydro-benzo [b] [1,4] diazepin-2-one derivatives F. HOFFMAN-LA ROCHE AG A SWISS COMPANY (CH) 2002-12-19 — — US disclosed
CN-1379764-A Benzodiazepine derivatives HOFFMANN LA ROCHE (CH) 2002-11-13 — — CN disclosed
CN-1379765-A Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist HOFFMANN LA ROCHE (CH) 2002-11-13 — — CN disclosed
WO-2002083652-A1 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II F. HOFFMANN-LA ROCHE AG (CH) 2002-10-24 — — WO disclosed
WO-2002083665-A1 DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I F. HOFFMANN-LA ROCHE AG (CH) 2002-10-24 — — WO disclosed
EP-1224175-A2 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2002-07-24 — — EP disclosed
EP-1224174-A2 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2002-07-24 — — EP disclosed
US-6407094-B1 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA HOFFMANN-LA ROCHE INC. 2002-06-18 — — US disclosed
WO-2001029012-A2 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2001-04-26 — — WO disclosed
WO-2001029011-A2 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2001-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11179371-B2 Triazole benzamide derivatives as GPR142 agonists GPR119, GPR142, GPR65 LOXL2 2160/4885TSHR 304/4885CYP4F2 961/4885
US-20020193367-A1 Dihydro-benzo [b] [1,4] diazepin-2-one derivatives CYP1B1, GRIN2B, BDKRB1 LOXL2 3737/4885TSHR 3817/4885CYP4F2 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback