Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 6/20 | 0.37 |
| ▸ | MGLL | Q99685 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573664 | 0.86 | ALDH1A1 (0.41) | HPGDFAAHMGLLKDM4EALDH1A1 | |
| SCHEMBL1573842 | 0.80 | ACHE (0.47) | HPGDRAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1574012 | 0.79 | HSP90AA1 (0.44) | RORCALDH1A1ELANESMN1; SMN2 | |
| SCHEMBL1574211 | 0.76 | NOTUM (0.50) | HPGDRAB9AAKR1C3KDM4EALDH1A1 | |
| SCHEMBL1573776 | 0.74 | ELANE (0.39) | RAB9AFAAHMGLLKDM4ERORC | |
| SCHEMBL6015477 | 0.74 | LMNA (0.32) | HPGDRAB9AALDH1A1 | |
| SCHEMBL11009351 | 0.71 | ELANE (0.64) | HPGDRORCELANE | |
| SCHEMBL1574092 | 0.69 | SMN1; SMN2 (0.55) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL26717871 | 0.69 | RBP4 (0.57) | HPGDRAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1573967 | 0.67 | ACHE (0.44) | HPGDRAB9AKDM4EALDH1A1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |