Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367686 | 0.88 | RORC (0.63) | RORCRAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL7570311 | 0.84 | KMT2A (0.54) | RAB9ASMN1; SMN2KDM4ENPC1KMT2A | |
| SCHEMBL15775319 | 0.84 | KDM4E (0.59) | RAB9AGAASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL15775601 | 0.82 | KDM4E (0.61) | KDM4EKMT2AALDH1A1POLB | |
| SCHEMBL18610497 | 0.82 | RORC (0.63) | RORCRAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL15775437 | 0.81 | KDM4E (0.57) | RAB9ASMN1; SMN2KDM4ENPC1KMT2A | |
| SCHEMBL15775229 | 0.81 | KDM4E (0.57) | RAB9ASMN1; SMN2KDM4ENPC1KMT2A | |
| SCHEMBL15775402 | 0.81 | KDM4E (0.77) | RAB9ASMN1; SMN2KDM4ENPC1KMT2A | |
| SCHEMBL15775332 | 0.79 | ALDH1A1 (0.55) | RAB9ASMN1; SMN2KDM4ENPC1KMT2A | |
| SCHEMBL15775220 | 0.79 | KDM4E (0.58) | RAB9AGAASMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |