Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775298 | 0.87 | ALDH1A1 (0.38) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL15775729 | 0.86 | CHRM5 (0.35) | SMN1; SMN2ALDH1A1PDE3BPDE3AMAOB | |
| SCHEMBL15775479 | 0.86 | NOTUM (0.39) | RAB9ANPC1RXFP1L3MBTL1CD274 | |
| SCHEMBL15775398 | 0.85 | RAB9A (0.40) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL15775756 | 0.85 | ALDH1A1 (0.42) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL15775423 | 0.83 | PDCD1 (0.38) | MAPTKDM4EPDE3BPDE3ACD274 | |
| SCHEMBL15775366 | 0.83 | RAB9A (0.38) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL15775204 | 0.81 | CYP19A1 (0.41) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL15775397 | 0.75 | ACHE (0.40) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL15775414 | 0.74 | SMN1; SMN2 (0.38) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |