Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 6/20 | 0.52 |
| ▸ | CA1 | P00915 | 6/20 | 0.52 |
| ▸ | CA2 | P00918 | 6/20 | 0.52 |
| ▸ | CA9 | Q16790 | 6/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17643003 | 0.87 | MEN1 (0.68) | KMT2AMEN1ATMGAAHSP90AA1 | |
| SCHEMBL17643006 | 0.80 | MEN1 (0.59) | KMT2AMEN1ATMGAAHSP90AA1 | |
| SCHEMBL17643007 | 0.78 | MEN1 (0.70) | KMT2AMEN1PTGS2GAAHSP90AA1 | |
| SCHEMBL17643200 | 0.74 | MEN1 (0.62) | KMT2AMEN1ATMGAAHSP90AA1 | |
| SCHEMBL17642998 | 0.73 | MEN1 (0.68) | KMT2AMEN1GAAHSP90AA1MAPT | |
| SCHEMBL497082 | 0.73 | PTGS2 (0.81) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL5758700 | 0.73 | KDM4E (0.67) | KMT2AMEN1GAAHSP90AA1MAPT | |
| SCHEMBL17629396 | 0.72 | MEN1 (0.70) | KMT2AMEN1GAAHSP90AA1MAPT | |
| SCHEMBL9953980 | 0.72 | ATM (0.51) | KMT2AMEN1ATMPTGS2MAPT | |
| SCHEMBL17642999 | 0.72 | MEN1 (0.66) | KMT2AMEN1GAAHSP90AA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166557-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | UNIV KANSAS (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170166557-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | UNIV KANSAS (US) | 2017-06-15 | — | — | US | disclosed |
| US-9580393-B2 | 6-substituted quinazolinone inhibitors | UNIVERSITY OF KANSAS (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580393-B2 | 6-substituted quinazolinone inhibitors | UNIVERSITY OF KANSAS (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150329499-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | SOUTHERN RESEARCH INSTITUTE | 2015-11-19 | — | — | US | disclosed |
| US-20150329499-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | SOUTHERN RESEARCH INSTITUTE | 2015-11-19 | — | — | US | disclosed |
| WO-2014093869-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2014-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329499-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | NDUFV3, NDUFV1, NDUFV2 | KMT2A 3270/4885MEN1 3635/4885ATM 4084/4885 |
| US-20170166557-A1 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS | NDUFV3, NDUFV2, NDUFV1 | KMT2A 3064/4885MEN1 3888/4885ATM 4076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.