Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chrysamine G. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.70 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.58 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.53 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.53 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.42 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.40 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | APP | P05067 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | BLVRB | P30043 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PHLPP2 | Q6ZVD8 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olsalazine SCHEMBL3476110 | 0.93 | MEN1 (0.66) | TDP1MEN1KMT2AAPPTHRB | |
| Olsalazine SCHEMBL29454399 | 0.93 | MEN1 (0.66) | TDP1MEN1KMT2AAPPTHRB | |
| Olsalazine SCHEMBL29767 | 0.93 | MEN1 (0.66) | TDP1MEN1KMT2AAPPTHRB | |
| SCHEMBL29950230 | 0.88 | MEN1 (0.61) | TDP1MEN1KMT2AAPPTHRB | |
| SCHEMBL27985065 | 0.88 | MEN1 (0.61) | TDP1MEN1KMT2AAPPTHRB | |
| SCHEMBL10784910 | 0.88 | MEN1 (0.59) | TDP1MEN1KMT2AAPPTHRB | |
| SCHEMBL1614891 | 0.87 | TDP1 (0.57) | TDP1MEN1KMT2AAPPTHRB | |
| Olsalazine SCHEMBL15201080 | 0.86 | MEN1 (0.79) | TDP1MEN1KMT2AAPPTHRB | |
| SCHEMBL428681 | 0.84 | PLCG1 (0.61) | TDP1MEN1KMT2AAPPTHRB | |
| SCHEMBL135508 | 0.84 | PLCG1 (0.61) | TDP1MEN1KMT2AAPPTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9808155-B2 | Apparatus to detect amyloid in a patient user's retina in a diagnosis, advancement and prognosis of alzheimer's disease, traumatic brain injury, macular degeneration and a plurality of neurodegenerative disorders and ocular diseases | NEUROVISION IMAGING LLC (US) | 2017-11-07 | — | — | US | claimed |
| US-20140176908-A1 | APPARATUS AND METHOD FOR DETECTING AMYLOID IN A RETINA IN A DIAGNOSIS, ADVANCEMENT, AND PROGNOSING OF ALZHEIMER'S DISEASE, TRAUMATIC BRAIN INJURY, MACULAR DEGENERATION AND A PLURALITY OF NEURODEGENERATIVE DISSORDERS AND OCULAR DISEASES | WILDCAT PARTNER HOLDINGS, LP | 2014-06-26 | — | — | US | claimed |
| US-9808155-B2 | Apparatus to detect amyloid in a patient user's retina in a diagnosis, advancement and prognosis of alzheimer's disease, traumatic brain injury, macular degeneration and a plurality of neurodegenerative disorders and ocular diseases | NEUROVISION IMAGING LLC (US) | 2017-11-07 | — | — | US | disclosed |
| US-20140176908-A1 | APPARATUS AND METHOD FOR DETECTING AMYLOID IN A RETINA IN A DIAGNOSIS, ADVANCEMENT, AND PROGNOSING OF ALZHEIMER'S DISEASE, TRAUMATIC BRAIN INJURY, MACULAR DEGENERATION AND A PLURALITY OF NEURODEGENERATIVE DISSORDERS AND OCULAR DISEASES | WILDCAT PARTNER HOLDINGS, LP | 2014-06-26 | — | — | US | disclosed |