SCHEMBL158269

SCHEMBL158269

O=C(O)CNc1ccccc1Br

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.50
RAB9A P51151 3/20 0.50
LMNA P02545 2/20 0.50
HTT P42858 2/20 0.50
MEN1 O00255 2/20 0.50
NPC1 O15118 1/20 0.50
ALDH1A1 P00352 4/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
MAPK1 P28482 1/20 0.46
PARP1 P09874 1/20 0.45
EGFR P00533 1/20 0.45
KDM4E B2RXH2 1/20 0.43
AGTR1 P30556 1/20 0.43
ITGB3 P05106 1/20 0.42
ITGB1 P05556 1/20 0.42
ITGAV P06756 1/20 0.42
ITGA5 P08648 1/20 0.42
ATM Q13315 1/20 0.42
CDC25A P30304 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29864421 1.00 KMT2A (0.50) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL5692314 0.85 PARP1 (0.51) KMT2ARAB9AMEN1ALDH1A1MAPK1
SCHEMBL7850241 0.84 RAB9A (0.45) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL28852119 0.84 ALDH1A1 (0.49) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL28470928 0.82 ALDH1A1 (0.51) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL29577048 0.81 ALDH1A1 (0.64) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL6090937 0.81 ALDH1A1 (0.64) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL25400139 0.79 ALDH1A1 (0.46) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL28326426 0.79 ALDH1A1 (0.46) KMT2ARAB9ALMNAHTTMEN1
SCHEMBL30536400 0.78 KMT2A (0.48) KMT2ARAB9ALMNAHTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102165950-B Bacteriostatic and bactericidal activity of phenylglycine derivative on escherichia coli UNIV ZHEJIANG 2014-02-26 CN claimed
US-8486370-B2 Heterocyclic ligands for integrin imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-07-16 US claimed
CN-102144992-B Bacteriostatic and bactericidal activity of phenylglycine derivatives to Staphylococcus aureus UNIV ZHEJIANG 2013-04-10 CN claimed
CN-102165950-A Bacteriostatic and bactericidal activity of phenylglycine derivative on escherichia coli UNIV ZHEJIANG 2011-08-31 CN claimed
CN-102144992-A Bacteriostatic and bactericidal activity of phenylglycine derivatives to Staphylococcus aureus UNIV ZHEJIANG 2011-08-10 CN claimed
US-20100310455-A1 Heterocyclic Ligands for Integrin Imaging and Therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-12-09 US claimed
US-7576175-B2 Amino acid terminated diphenylurea derivatives; display high binding affinity, specificity, and stability; use in treating cancer, inflammatory diseases, and autoimmune diseases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-08-18 US claimed
WO-2008031016-A2 HETEROCYCLIC LIGANDS FOR INTEGRIN IMAGING AND THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-03-13 WO claimed
WO-2005122379-A9 ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY UNIV CALIFORNIA (US) 2006-03-09 WO claimed
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-01-26 US claimed
WO-2005122379-A2 ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-12-22 WO claimed
US-4946761-A POLYMER CONTAINING CARBOXYL END GROUPS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-07 US claimed
US-20260083852-A1 PROTEOGLYCAN MIMETICS FOR ENHANCED WOUND HEALING, ANGIOGENESIS, AND VASCULAR REPAIR UNIV CALIFORNIA (US) 2026-03-26 US disclosed
US-12485182-B2 Proteoglycan mimetics for enhanced wound healing, angiogenesis, and vascular repair THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-12-02 US disclosed
US-20250302971-A1 Therapeutic Nanomaterials UNIV CONNECTICUT (US) 2025-10-02 US disclosed
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF UNIVERSITY OF CONNECTICUT (US) 2025-10-02 US disclosed
US-5395733-A Unsaturated polymer layer that can be decarboxylated on exposure to light and sensitizers FUJI PHOTO FILM CO., LTD. (JP) 1995-03-07 US disclosed
EP-0458485-A2 Image forming layer Fuji Photo Film Co., Ltd. (JP) 1991-11-27 EP disclosed
US-4946761-A POLYMER CONTAINING CARBOXYL END GROUPS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-07 US disclosed
US-4405705-A HYDROPHILIC TOYO BOSEKI KABUSHIKI KAISHA T/A TOYOBA CO., LTD. (JP) 1983-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302971-A1 Therapeutic Nanomaterials TIE1, TEKT1, POLRMT KMT2A 384/4885RAB9A 2256/4885LMNA 1574/4885
US-20100310455-A1 Heterocyclic Ligands for Integrin Imaging and Therapy ITGA1, ITGAL, ITGA4 KMT2A 2701/4885RAB9A 1592/4885LMNA 2248/4885
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF JAK2, JAK1, CHMP4B KMT2A 1471/4885RAB9A 694/4885LMNA 1531/4885
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy ITGA4, ITGB4, ITGA1 KMT2A 3460/4885RAB9A 2130/4885LMNA 2391/4885
US-12485182-B2 Proteoglycan mimetics for enhanced wound healing, angiogenesis, and vascular repair PDGFA, PDGFRB, TEK KMT2A 4334/4885RAB9A 3778/4885LMNA 431/4885
US-20260083852-A1 PROTEOGLYCAN MIMETICS FOR ENHANCED WOUND HEALING, ANGIOGENESIS, AND VASCULAR REPAIR PDGFA, DCLRE1A, PDGFRA KMT2A 2690/4885RAB9A 2150/4885LMNA 401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.