SCHEMBL15840579

SCHEMBL15840579

CC(C)(O)c1c(N)cnc2ccc(F)c(Cl)c12

nearest known ligand 0.36

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TNF P01375 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17278413 0.84 TNF (0.36) TNF
SCHEMBL15819804 0.83 TNF (0.34) TNF
SCHEMBL15840576 0.79 PARP1 (0.38) TNF
SCHEMBL17301337 0.78 PDPK1 (0.33) TNF
SCHEMBL15840573 0.78 ALOX5AP (0.31)
SCHEMBL15840575 0.74 CNR2 (0.34) TNF
SCHEMBL15840581 0.74 NR4A2 (0.34)
SCHEMBL15819920 0.74 NR4A2 (0.49) TNF
SCHEMBL22304289 0.71 IDO1 (0.34)
SCHEMBL6700570 0.68 ALDH1A1 (0.31) TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023192372-A1 METHODS OF TREATING SJÖGREN-LARSSEN SYNDROME ALDEYRA THERAPEUTICS, INC. (US) 2023-10-05 WO disclosed
US-11771664-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2023-10-03 US disclosed
US-11771664-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2023-10-03 US disclosed
US-20230293527-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230293527-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230248727-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-08-10 US disclosed
US-20230248727-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-08-10 US disclosed
US-11701331-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2023-07-18 US disclosed
US-11701331-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2023-07-18 US disclosed
US-20230149383-A1 QUINOLINE COMPOUNDS FOR TREATING LUNG, LIVER, AND KIDNEY DISEASES, DISORDERS, OR CONDITIONS ALDEYRA THERAPEUTICS, INC. 2023-05-18 US disclosed
US-9687481-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2017-06-27 US disclosed
US-9687481-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2017-06-27 US disclosed
US-9604997-B2 Peri-carbinols ALDEYRA THERAPEUTICS, INC. (US) 2017-03-28 US disclosed
US-9604997-B2 Peri-carbinols ALDEYRA THERAPEUTICS, INC. (US) 2017-03-28 US disclosed
US-20150344432-A1 PERI-CARBINOLS Ricerca Biosciences, LLC 2015-12-03 US disclosed
US-20150344432-A1 PERI-CARBINOLS Ricerca Biosciences, LLC 2015-12-03 US disclosed
US-20150335632-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. (F/K/A ALDEXA THERAPEUTICS, INC. F/K/A NEURON SYSTEMS, INC.) 2015-11-26 US disclosed
US-20150335632-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. (F/K/A ALDEXA THERAPEUTICS, INC. F/K/A NEURON SYSTEMS, INC.) 2015-11-26 US disclosed
WO-2014116836-A2 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEXA THERAPEUTICS, INC. (US) 2014-07-31 WO disclosed
WO-2014100425-A1 PERI-CARBINOLS ALDEXA THERAPEUTICS, INC. (US) 2014-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150344432-A1 PERI-CARBINOLS PLIN1, PLIN3, PLIN5 TNF 407/4885
US-20230293527-A1 TREATMENT OF INFLAMMATORY DISORDERS TNF, NFKBIA, LTB4R2 TNF 1/4885
US-11771664-B2 Toxic aldehyde related diseases and treatment ALDH1A2, ALDH2, ALDH1A1 TNF 210/4885
US-11701331-B2 Toxic aldehyde related diseases and treatment ALDH1A2, ALDH2, ALDH1A1 TNF 210/4885
US-20230248727-A1 TREATMENT OF INFLAMMATORY DISORDERS TNF, NFKBIA, LTB4R2 TNF 1/4885
US-20230149383-A1 QUINOLINE COMPOUNDS FOR TREATING LUNG, LIVER, AND KIDNEY DISEASES, DISORDERS, OR CONDITIONS GLS, PYGL, REN TNF 2536/4885
US-20150335632-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 TNF 210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.