SCHEMBL15905413

SCHEMBL15905413

CC(=O)Nc1cc(Cl)c(F)c(C(=O)C2CC2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RORC P51449 3/20 0.44
TYK2 P29597 1/20 0.44
NAMPT P43490 1/20 0.43
NPC1 O15118 2/20 0.41
KMT2A Q03164 6/20 0.39
MEN1 O00255 5/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
NR1I2 O75469 1/20 0.39
AHR P35869 1/20 0.39
PYGL P06737 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
HTT P42858 1/20 0.38
IDO1 P14902 1/20 0.37
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17272852 0.84 TYK2 (0.41) RORCTYK2NAMPTNPC1KMT2A
SCHEMBL17289462 0.84 TYK2 (0.41) RORCTYK2NAMPTNPC1KMT2A
SCHEMBL15903443 0.74 TYK2 (0.36) TYK2NPC1KMT2AMEN1ALDH1A1
SCHEMBL20535682 0.69 LMNA (0.56) RORCKMT2AMEN1ALDH1A1MAPT
SCHEMBL12332367 0.67 LMNA (0.54) RORCKMT2AMEN1ALDH1A1MAPT
SCHEMBL6566913 0.67 LMNA (0.59) RORCNPC1KMT2AMEN1ALDH1A1
SCHEMBL28219173 0.67 MEN1 (0.38) RORCNPC1KMT2AMEN1ALDH1A1
SCHEMBL13690012 0.66 LMNA (0.48) RORCTYK2KMT2AMEN1ALDH1A1
SCHEMBL15544520 0.66 MEN1 (0.48) RORCNPC1KMT2AMEN1ALDH1A1
SCHEMBL13690016 0.66 RORC (0.53) RORCKMT2AMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2948149-B1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS INC (US) 2026-03-04 EP disclosed
US-20250127733-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. 2025-04-24 US disclosed
US-20240189260-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. 2024-06-13 US disclosed
US-11771664-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2023-10-03 US disclosed
US-11701331-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2023-07-18 US disclosed
US-20220354857-A1 ALDEHYDE CONJUGATES AND USES THEREOF ALDEYRA THERAPEUTICS, INC. 2022-11-10 US disclosed
US-20220202745-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. 2022-06-30 US disclosed
US-20210275469-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. 2021-09-09 US disclosed
US-11007157-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2021-05-18 US disclosed
US-20200368182-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEXA THERAPEUTICS, INC. 2020-11-26 US disclosed
US-20180250306-A1 ALDEHYDE CONJUGATES AND USES THEREOF ALDEYRA THERAPEUTICS, INC. 2018-09-06 US disclosed
EP-3337470-A1 ALDEHYDE CONJUGATES AND USES THEREOF Aldeyra Therapeutics, Inc. (US) 2018-06-27 EP disclosed
CN-108135867-A ALDEHYDE CONJUGATES AND USES THEREOF 奥尔德拉医疗公司 2018-06-08 CN disclosed
US-20170239196-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. (F/K/A ALDEXA THERAPEUTICS, INC. F/K/A NEURON SYSTEMS, INC.) 2017-08-24 US disclosed
US-9687481-B2 Toxic aldehyde related diseases and treatment ALDEYRA THERAPEUTICS, INC. (US) 2017-06-27 US disclosed
WO-2017035082-A1 ALDEHYDE CONJUGATES AND USES THEREOF ALDEYRA THERAPEUTICS, INC. (US) 2017-03-02 WO disclosed
US-20150344447-A1 NOVEL TRAPS IN THE TREATMENT OF MACULAR DEGENERATION ALDEXA THERAPEUTICS, INC. 2015-12-03 US disclosed
EP-2948436-A1 NOVEL TRAPS IN THE TREATMENT OF MACULAR DEGENERATION Aldeyra Therapeutics, Inc. (US) 2015-12-02 EP disclosed
US-20150335632-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDEYRA THERAPEUTICS, INC. (F/K/A ALDEXA THERAPEUTICS, INC. F/K/A NEURON SYSTEMS, INC.) 2015-11-26 US disclosed
WO-2014116593-A1 NOVEL TRAPS IN THE TREATMENT OF MACULAR DEGENERATION ALDEXA THERAPEUTICS, INC. (US) 2014-07-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210275469-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20170239196-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20150344447-A1 NOVEL TRAPS IN THE TREATMENT OF MACULAR DEGENERATION PDE6C, PDE6D, PDE6A RORC 1858/4885TYK2 4567/4885NAMPT 36/4885
US-11007157-B2 Toxic aldehyde related diseases and treatment ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20200368182-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20250127733-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-11771664-B2 Toxic aldehyde related diseases and treatment ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-11701331-B2 Toxic aldehyde related diseases and treatment ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20180250306-A1 ALDEHYDE CONJUGATES AND USES THEREOF ALDH1A2, AOX1, ALDH2 RORC 2495/4885TYK2 2800/4885NAMPT 1331/4885
US-20220202745-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20150335632-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885
US-20220354857-A1 ALDEHYDE CONJUGATES AND USES THEREOF ALDH1A2, AOX1, ALDH2 RORC 2495/4885TYK2 2800/4885NAMPT 1331/4885
US-20240189260-A1 TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT ALDH1A2, ALDH2, ALDH1A1 RORC 2122/4885TYK2 3739/4885NAMPT 1780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.