Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | PPIB | P23284 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | PPIG | Q13427 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15146682 | 0.89 | L3MBTL1 (0.47) | PPIDMAPTL3MBTL1SMN1; SMN2ATM | |
| SCHEMBL15144130 | 0.84 | SMN1; SMN2 (0.46) | PPIDMAPTL3MBTL1SMN1; SMN2ATM | |
| SCHEMBL631833 | 0.84 | ALDH1A1 (0.44) | MAPTL3MBTL1SMN1; SMN2ATMLMNA | |
| SCHEMBL18196153 | 0.83 | SMN1; SMN2 (0.44) | PPIDMAPTL3MBTL1SMN1; SMN2ATM | |
| SCHEMBL1285009 | 0.80 | PPID (0.64) | PPIDMAPTNAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL2173670 | 0.77 | PPID (0.51) | PPIDMAPTNAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL3224087 | 0.74 | PPID (0.56) | PPIDMAPTNAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL23478555 | 0.74 | ALDH1A1 (0.45) | PPIDL3MBTL1SMN1; SMN2LMNAPOLB | |
| SCHEMBL14531434 | 0.74 | PPID (0.58) | PPIDMAPTNAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL13430501 | 0.73 | PPID (0.46) | PPIDMAPTNAMPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957516-B1 | ALFA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS | CHOONGWAE PHARMA CORP (KR) | 2016-03-09 | — | — | EP | disclosed |
| US-9193734-B2 | Alpha helix mimetics and methods relating thereto | PRISM PHARMA CO., LTD. (JP) | 2015-11-24 | — | — | US | disclosed |
| EP-2303887-B1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORP (JP) | 2015-08-05 | — | — | EP | disclosed |
| US-8940739-B2 | Compound of a reverse-turn mimetic and a production method and use therefor | JW PHARMACEUTICAL CORPORATION (KR) | 2015-01-27 | — | — | US | disclosed |
| US-8940739-B2 | Compound of a reverse-turn mimetic and a production method and use therefor | JW PHARMACEUTICAL CORPORATION (KR) | 2015-01-27 | — | — | US | disclosed |
| EP-2650295-A1 | Alpha helix mimetics and methods relating thereto | Prism Biolab Corporation (JP) | 2013-10-16 | — | — | EP | disclosed |
| US-20130267482-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM PHARMA CO., LTD. (JP) | 2013-10-10 | — | — | US | disclosed |
| US-20130196972-A1 | NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR | JW PHARMACEUTICAL CORPORATION (KR) | 2013-08-01 | — | — | US | disclosed |
| US-20130196972-A1 | NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR | JW PHARMACEUTICAL CORPORATION (KR) | 2013-08-01 | — | — | US | disclosed |
| US-8455488-B2 | Alpha helix mimetics and methods relating thereto | PRISM BIOLAB CORPORATION (JP) | 2013-06-04 | — | — | US | disclosed |
| US-20100267672-A1 | NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF | CHOONGWAE PHARMA CORPORATION (KR) | 2010-10-21 | — | — | US | disclosed |
| US-20100267672-A1 | NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF | CHOONGWAE PHARMA CORPORATION (KR) | 2010-10-21 | — | — | US | disclosed |
| US-20100069333-A1 | ALPHA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS | CHOONGWAE PHARMA CORPORATION (KR) | 2010-03-18 | — | — | US | disclosed |
| US-20090176742-A1 | METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS | UNIVERSITY OF WASHINGTON (US) | 2009-07-09 | — | — | US | disclosed |
| US-20080242669-A1 | METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS | UNIVERSITY OF WASHINGTON (US) | 2008-10-02 | — | — | US | disclosed |
| EP-1957516-A2 | ALFA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS | Choongwae Pharma Corporation (KR) | 2008-08-20 | — | — | EP | disclosed |
| US-20080009500-A1 | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders | INSTITUTE FOR CHEMICAL GENOMICS | 2008-01-10 | — | — | US | disclosed |
| US-20070129353-A1 | Alpha-helix mimetics and method relating to the treatment of cancer stem cells | INSTITUTE FOR CHEMICAL GENOMICS | 2007-06-07 | — | — | US | disclosed |
| WO-2007056513-A1 | α-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS | INSTITUTE FOR CHEMICAL GENOMICS (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056593-A2 | α-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS | CHOONGWAE PHARMA CORPORATION (KR) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009500-A1 | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders | COL1A1, COL2A1, PLOD3 | PPID 2217/4885MAPT 2446/4885NAMPT 1310/4885 |
| US-20080242669-A1 | METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS | NR3C1, RXFP3, NR2E3 | PPID 4027/4885MAPT 4304/4885NAMPT 2638/4885 |
| US-20130267482-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | COL1A1, PLOD3, THPO | PPID 1558/4885MAPT 1429/4885NAMPT 2186/4885 |
| US-20070129353-A1 | Alpha-helix mimetics and method relating to the treatment of cancer stem cells | MCL1, HNF4A, THPO | PPID 2040/4885MAPT 2031/4885NAMPT 1210/4885 |
| US-20100267672-A1 | NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF | MCL1, THPO, FLT3 | PPID 2402/4885MAPT 4476/4885NAMPT 1052/4885 |
| US-20090176742-A1 | METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS | RXFP3, NR3C1, NR2E3 | PPID 4026/4885MAPT 4249/4885NAMPT 2709/4885 |
| US-20130196972-A1 | NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR | MCL1, THPO, MYADM | PPID 1843/4885MAPT 4644/4885NAMPT 320/4885 |
| US-20100069333-A1 | ALPHA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS | MCL1, HNF4A, THPO | PPID 1965/4885MAPT 2031/4885NAMPT 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.