Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.88 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.82 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.82 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.82 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.82 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.82 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.82 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | EYA2 | O00167 | 1/20 | 0.88 |
| ▸ | APP | P05067 | 1/20 | 0.88 |
| ▸ | BLM | P54132 | 2/20 | 0.82 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | DRD1 | P21728 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL5389310 | 1.00 | TDP1 (0.88) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL5391298 | 1.00 | TDP1 (0.88) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL120660 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL4287868 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL11181102 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL537771 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL1007448 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL1933603 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL9640564 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL464945 | 0.97 | TDP1 (0.93) | TDP1EYA2APPACEBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868170-A | ANTIINFLAMMATORY, OXIDATION RESISTANCE | E. R. SQUIBB & SONS, INC. (US) | 1989-09-19 | — | — | US | claimed |
| EP-4328305-A2 | METHOD OF PURIFYING POLYPEPTIDES | CSL Ltd. (AU) | 2024-02-28 | — | — | EP | disclosed |
| EP-4262836-A1 | WATERCRESS EXTRACTION METHOD | University of Exeter (GB) | 2023-10-25 | — | — | EP | disclosed |
| EP-3715356-B1 | METHOD OF PURIFYING POLYPEPTIDES | CSL LTD (AU) | 2023-10-11 | — | — | EP | disclosed |
| WO-2023181468-A1 | KIT FOR ISOLATING CIRCULATING TUMOR CELLS, CONTAINER FOR ISOLATING CIRCULATING TUMOR CELLS, AND METHOD FOR ISOLATING CIRCULATING TUMOR CELLS | 積水メディカル株式会社 | 2023-09-28 | — | — | WO | disclosed |
| WO-2023145137-A1 | BLOOD COLLECTION CONTAINER, METHOD FOR SEPARATING PLASMA, METHOD FOR SEPARATING EXTRACELLULAR FREE NUCLEIC ACID, AND METHOD FOR SEPARATING EXTRACELLULAR VESICLE | 積水メディカル株式会社 | 2023-08-03 | — | — | WO | disclosed |
| EP-3483603-B1 | HEMOGLOBIN LIQUID PREPARATION AND LIQUID CHROMATOGRAPHY METHOD FOR MEASURING HEMOGLOBIN COMPONENT | TOSOH CORP (JP) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022250142-A1 | BLOOD COLLECTION CONTAINER, METHOD FOR SEPARATING PLASMA, METHOD FOR SEPARATING EXTRACELLULAR FREE NUCLEIC ACID, AND METHOD FOR SEPARATING EXTRACELLULAR VESICLE | 積水メディカル株式会社 | 2022-12-01 | — | — | WO | disclosed |
| WO-2022129618-A1 | WATERCRESS EXTRACTION METHOD | UNIVERSITY OF EXETER (GB) | 2022-06-23 | — | — | WO | disclosed |
| WO-2021112119-A1 | BLOOD COLLECTION CONTAINER AND PLASMA SEPARATION METHOD | 積水メディカル株式会社 | 2021-06-10 | — | — | WO | disclosed |
| US-5506094-A | Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction | EASTMAN KODAK COMPANY (US) | 1996-04-09 | — | — | US | disclosed |
| US-5460930-A | Fade resistance in bleach solutions, cold storage | EASTMAN KODAK COMPANY (US) | 1995-10-24 | — | — | US | disclosed |
| EP-0655648-A1 | Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction | EASTMAN KODAK COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| EP-0651286-A1 | Photographic elements containing indoaniline dummy dyes | EASTMAN KODAK COMPANY (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0651288-A1 | Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction | EASTMAN KODAK COMPANY (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0636934-A1 | Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction | EASTMAN KODAK COMPANY (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0636936-A1 | Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction | EASTMAN KODAK COMPANY (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0386963-B1 | Preventing off-flavor in certain alitame-sweetened beverages | PFIZER (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0386963-A2 | Preventing off-flavor in certain alitame-sweetened beverages | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4868170-A | ANTIINFLAMMATORY, OXIDATION RESISTANCE | E. R. SQUIBB & SONS, INC. (US) | 1989-09-19 | — | — | US | disclosed |