Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | PKLR | P30613 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004020 | 0.93 | PKM (0.40) | LMNASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL16004326 | 0.83 | PKM (0.46) | LMNAMEN1MAPK1KMT2AMAPT | |
| SCHEMBL16004228 | 0.82 | PKM (0.52) | LMNASMN1; SMN2PKMPKLR | |
| SCHEMBL16004012 | 0.82 | NPC1 (0.41) | LMNAMEN1MAPK1KMT2ANTRK1 | |
| SCHEMBL16004229 | 0.82 | PKM (0.46) | LMNAMAPK1KMT2AMAPTPKM | |
| SCHEMBL16004257 | 0.81 | PKM (0.50) | LMNAMEN1MAPK1KMT2AMAPT | |
| SCHEMBL16004163 | 0.81 | PKM (0.49) | LMNAMEN1MAPK1KMT2AMAPT | |
| SCHEMBL16004164 | 0.80 | RORC (0.44) | LMNAMEN1KMT2AMAPTPKM | |
| SCHEMBL16004256 | 0.80 | L3MBTL1 (0.42) | LMNASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL16004262 | 0.80 | L3MBTL1 (0.45) | LMNASMN1; SMN2MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |