SCHEMBL16013207

SCHEMBL16013207

[N-]=[N+]=NCCCOC(=O)CN=[N+]=[N-]

nearest known ligand 0.43

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.33
TLR2 O60603 1/20 0.33
TLR1 Q15399 1/20 0.33
NAAA Q02083 1/20 0.31
RAD52 P43351 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17404783 0.92 TLR2 (0.34) TLR2TLR1NAAARAD52NPSR1
SCHEMBL20591071 0.87 DGKA (0.31) TLR2TLR1
SCHEMBL17039155 0.85 NAAA (0.46) NAAARAD52NPSR1
SCHEMBL17411107 0.85 CYP1A2 (0.33) TLR2TLR1
Ethylene SCHEMBL23781324 0.83
SCHEMBL26626698 0.82 NAAA (0.56) NAAARAD52NPSR1
SCHEMBL23781323 0.82 ALDH1A1 (0.34)
SCHEMBL14222098 0.82 ALDH1A1 (0.34)
SCHEMBL15417592 0.80 CYP2C19 (0.31)
SCHEMBL28735928 0.80 NAAA (0.35) NAAARAD52NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2964224-B1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2024-07-03 EP disclosed
US-10113033-B2 Polymer conjugate for delivery of a bioactive agent POLYACTIVA PTY LTD (AU) 2018-10-30 US disclosed
US-10111886-B2 Polymer conjugate for delivery of a bioactive agent POLYACTIVA PTY LTD (AU) 2018-10-30 US disclosed
US-20170216308-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2017-08-03 US disclosed
US-20170216308-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2017-08-03 US disclosed
US-20170182173-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2017-06-29 US disclosed
US-20170182173-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2017-06-29 US disclosed
US-9572892-B2 Polymer conjugate for delivery of a bioactive agent POLYACTIVA PTY LTD (AU) 2017-02-21 US disclosed
US-9572892-B2 Polymer conjugate for delivery of a bioactive agent POLYACTIVA PTY LTD (AU) 2017-02-21 US disclosed
EP-2964224-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT Polyactiva Pty Ltd (AU) 2016-01-13 EP disclosed
US-20160000929-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2016-01-07 US disclosed
US-20160000929-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2016-01-07 US disclosed
WO-2014134689-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2014-09-12 WO disclosed
WO-2014134689-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT POLYACTIVA PTY LTD (AU) 2014-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10113033-B2 Polymer conjugate for delivery of a bioactive agent PTGIS, PTGIR, PGF ALOX5 24/4885TLR2 3515/4885TLR1 2536/4885
US-10111886-B2 Polymer conjugate for delivery of a bioactive agent PTGIS, PTGIR, PGF ALOX5 37/4885TLR2 3932/4885TLR1 3168/4885
US-20160000929-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT PTGIS, PTGIR, PGF ALOX5 38/4885TLR2 3397/4885TLR1 2747/4885
US-20170216308-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT PTGIS, PTGIR, PGF ALOX5 37/4885TLR2 3932/4885TLR1 3168/4885
US-20170182173-A1 POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT PTGIS, PTGIR, PGF ALOX5 24/4885TLR2 3515/4885TLR1 2536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.