Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440392 | 0.75 | CTSB (0.49) | SIRT2HPRT1TDP1CTSBCYP3A4 | |
| SCHEMBL772678 | 0.74 | CYP3A4 (0.59) | MAOAMAOBTDP1POLBCYP3A4 | |
| SCHEMBL1323425 | 0.74 | CASP6 (0.53) | SIRT2MAOAMAOBHPRT1TDP1 | |
| SCHEMBL28075704 | 0.73 | MAOA (0.44) | MAOAMAOBTDP1POLBCYP3A4 | |
| SCHEMBL338831 | 0.73 | PARP1 (0.51) | TDP1POLBCYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL7896263 | 0.73 | PPOX (0.46) | MAOATDP1POLBCYP3A4TP53 | |
| SCHEMBL30050991 | 0.73 | SMN1; SMN2 (0.61) | TDP1POLBCYP3A4ALDH1A1GSK3B | |
| SCHEMBL284027 | 0.73 | SMN1; SMN2 (0.61) | TDP1POLBCYP3A4ALDH1A1GSK3B | |
| SCHEMBL2114118 | 0.73 | GSK3B (0.57) | TDP1POLBCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL11248196 | 0.73 | GSK3B (0.45) | ALDH1A1GSK3BCHEK1WEE1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10451604-B2 | Methods of measuring hydrogen sulfide concentrations in reservoir fluids | SHELL OIL COMPANY (US) | 2019-10-22 | — | — | US | claimed |
| EP-2046817-B1 | IMPROVED PROCESS FOR THE PREPARATION OF COPOLYMER-1 | MOMENTA PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | EP | claimed |
| US-20080021192-A1 | PROCESS FOR THE PREPARATION OF COPOLYMER-1 | MOMENTA PHARMACEUTICALS, INC. (US) | 2008-01-24 | — | — | US | claimed |
| EP-0698230-A1 | CHEMICALLY AMPLIFIED PHOTORESIST | International Business Machines Corporation (US) | 1996-02-28 | — | — | EP | claimed |
| JP-H08501890-A | — | — | 1996-02-27 | — | — | JP | claimed |
| EP-0698230-A4 | CHEMICALLY AMPLIFIED PHOTORESIST | IBM (US) | 1995-10-24 | — | — | EP | claimed |
| WO-1994010608-A9 | CHEMICALLY AMPLIFIED PHOTORESIST | — | 1994-07-21 | — | — | WO | claimed |
| WO-1994010608-A1 | CHEMICALLY AMPLIFIED PHOTORESIST | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1994-05-11 | — | — | WO | claimed |
| US-4181530-A | ELECTRON ATTRACTING PHTHALIMIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-01-01 | — | — | US | claimed |
| US-11718645-B2 | Macrocyclic therapeutic agents, methods of manufacture, and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-08-08 | — | — | US | disclosed |
| US-11325944-B2 | Macrocyclic peptides and derivatives thereof with opioid activity | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-05-10 | — | — | US | disclosed |
| EP-3107919-B1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIV FLORIDA (US) | 2021-01-27 | — | — | EP | disclosed |
| US-20200317732-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2020-10-08 | — | — | US | disclosed |
| US-20200109168-A1 | MACROCYCLIC PEPTIDES AND DERIVATIVES THEREOF WITH OPIOID ACTIVITY | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2020-04-09 | — | — | US | disclosed |
| WO-1994010608-A9 | CHEMICALLY AMPLIFIED PHOTORESIST | — | 1994-07-21 | — | — | WO | disclosed |
| WO-1994010608-A1 | CHEMICALLY AMPLIFIED PHOTORESIST | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1994-05-11 | — | — | WO | disclosed |
| EP-0010994-B1 | PROCESS FOR PRODUCING SUBSTITUTED NAPHTHALIC ACID COMPOUNDS | BRENT CHEMICALS INTERNATIONAL PLC (GB) | 1983-04-20 | — | — | EP | disclosed |
| US-4181530-A | ELECTRON ATTRACTING PHTHALIMIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-01-01 | — | — | US | disclosed |
| US-4146720-A | RODENTICIDES AND ANTITUMOR AGENTS | LABORATORIOS MADE, S.A. (ES) | 1979-03-27 | — | — | US | disclosed |
| US-3963779-A | 1,1-BIS(N,N-DIPHENYL-ALKYL-AMINO-PHENYL)-ALKANE | MITSUBISHI PAPER MILLS, LTD. (JA) | 1976-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200109168-A1 | MACROCYCLIC PEPTIDES AND DERIVATIVES THEREOF WITH OPIOID ACTIVITY | OPRL1, OPRM1, OPRK1 | SIRT2 4627/4885MAOA 779/4885MAOB 754/4885 |
| US-11718645-B2 | Macrocyclic therapeutic agents, methods of manufacture, and methods of treatment | NFATC1, MCL1, ICOS | SIRT2 1605/4885MAOA 3456/4885MAOB 3571/4885 |
| US-20200317732-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | NFATC1, MCL1, ICOS | SIRT2 1605/4885MAOA 3456/4885MAOB 3571/4885 |
| US-11325944-B2 | Macrocyclic peptides and derivatives thereof with opioid activity | OPRL1, OPRM1, OPRK1 | SIRT2 4627/4885MAOA 779/4885MAOB 754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.