SCHEMBL16015010

SCHEMBL16015010

COc1cc(C)cc(-c2ccc(C)cc2O)c1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.48
ERN1 O75460 1/20 0.46
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 3/20 0.43
MAPT P10636 3/20 0.43
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
APEX1 P27695 1/20 0.43
MPI P34949 1/20 0.43
RECQL P46063 1/20 0.43
KMT2A Q03164 1/20 0.43
TRPA1 O75762 1/20 0.42
TNKS2 Q9H2K2 2/20 0.41
IDO1 P14902 1/20 0.41
TDO2 P48775 1/20 0.41
PTPN1 P18031 1/20 0.41
CYP3A4 P08684 2/20 0.40
SELL P14151 1/20 0.40
SELP P16109 1/20 0.40
SELE P16581 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18523530 0.91 ACHE (0.50) ACHEERN1ALDH1A1KDM4EMAPT
SCHEMBL16014627 0.89 ACHE (0.48) ACHEERN1ALDH1A1MAPTGAA
SCHEMBL890499 0.87 ACHE (0.55) ACHEERN1ALDH1A1KDM4EMAPT
SCHEMBL7520392 0.87 ERN1 (0.57) ACHEERN1ALDH1A1KDM4EMAPT
SCHEMBL11950304 0.85 ACHE (0.56) ACHEALDH1A1KDM4EMAPTPOLB
SCHEMBL17431234 0.84 KMT2A (0.42) ACHEALDH1A1KDM4EMAPTPOLB
SCHEMBL16024769 0.82 TRPA1 (0.46) ERN1ALDH1A1GAAKMT2ATRPA1
SCHEMBL16024749 0.82 ALDH1A1 (0.44) ERN1ALDH1A1MAPTGAARECQL
SCHEMBL16024745 0.82 ERN1 (0.46) ACHEERN1ALDH1A1KDM4EMAPT
SCHEMBL18826204 0.81 SELL (0.56) ACHEALDH1A1KDM4EMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3029056-B1 BIS-PHOSPHITES WITH AN ASYMMETRIC BIARYL CENTRAL COMPONENT EVONIK DEGUSSA GMBH (DE) 2018-11-07 EP disclosed
EP-3029045-B1 Bis-phosphites with 2.3 -biphenol unit as central component EVONIK DEGUSSA GMBH (DE) 2018-06-13 EP disclosed
EP-3029045-B1 Bis-phosphites with 2.3 -biphenol unit as central component EVONIK DEGUSSA GMBH (DE) 2018-06-13 EP disclosed
US-9982001-B2 Bisphosphites having an unsymmetric central biaryl unit EVONIK DEGUSSA GMBH (DE) 2018-05-29 US disclosed
US-9982001-B2 Bisphosphites having an unsymmetric central biaryl unit EVONIK DEGUSSA GMBH (DE) 2018-05-29 US disclosed
US-9982001-B2 Bisphosphites having an unsymmetric central biaryl unit EVONIK DEGUSSA GMBH (DE) 2018-05-29 US disclosed
EP-3029050-B1 Bis-phosphites with a naphthyl-phenyl unit as fin component EVONIK DEGUSSA GMBH (DE) 2018-02-28 EP disclosed
EP-3029050-B1 Bis-phosphites with a naphthyl-phenyl unit as fin component EVONIK DEGUSSA GMBH (DE) 2018-02-28 EP disclosed
CN-105669758-B Single phosphite ester with asymmetric biaryl unit 赢创德固赛有限公司 2018-02-13 CN disclosed
US-9879353-B2 Electrochemical coupling of two phenols which differ in their oxidation potential EVONIK DEGUSSA GMBH (DE) 2018-01-30 US disclosed
EP-3029057-A1 BIS-PHOSPHITES WITH AN ASYMMETRIC BIARYL CENTRAL COMPONENT Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
EP-3029050-A1 Bis-phosphites with a naphthyl-phenyl unit as fin component Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
EP-3029044-A1 Bis-phosphites with an asymmetric biaryl central component Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
US-20160010225-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL EVONIK DEGUSSA GMBH (DE) 2016-01-14 US disclosed
US-20160010225-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL EVONIK DEGUSSA GMBH (DE) 2016-01-14 US disclosed
US-20160010225-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL EVONIK DEGUSSA GMBH (DE) 2016-01-14 US disclosed
EP-2964813-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL Evonik Degussa GmbH (DE) 2016-01-13 EP disclosed
CN-105164318-A Electrochemical coupling of two phenols which differ in their oxidation potential EVONIK DEGUSSA GMBH 2015-12-16 CN disclosed
WO-2014135236-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL EVONIK INDUSTRIES AG (DE) 2014-09-12 WO disclosed
WO-2014135236-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL EVONIK INDUSTRIES AG (DE) 2014-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160010225-A1 ELECTROCHEMICAL COUPLING OF TWO PHENOLS WHICH DIFFER IN THEIR OXIDATION POTENTIAL COMT, MT-CO2, CYP11B2 ACHE 257/4885ERN1 3827/4885ALDH1A1 902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.