SCHEMBL16016282

SCHEMBL16016282

C/C=C/c1ccc(O)c(C)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.67
TYR P14679 1/20 0.58
BACE1 P56817 1/20 0.53
LCK P06239 2/20 0.48
TP53 P04637 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
CYP3A4 P08684 2/20 0.46
ATM Q13315 1/20 0.46
PDE10A Q9Y233 1/20 0.45
TUBB1 Q9H4B7 2/20 0.44
PTGS1 P23219 4/20 0.44
ALOX5 P09917 3/20 0.44
PTGS2 P35354 3/20 0.44
ESR1 P03372 3/20 0.43
ESR2 Q92731 2/20 0.43
NQO2 P16083 1/20 0.42
IAPP P10997 1/20 0.41
RGS12 O14924 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2186413 1.00 CNR2 (0.67) CNR2TYRBACE1LCKTP53
SCHEMBL2186412 1.00 CNR2 (0.67) CNR2TYRBACE1LCKTP53
SCHEMBL1824386 0.89 LCK (0.61) CNR2BACE1LCKTP53TDP1
SCHEMBL1824384 0.89 LCK (0.61) CNR2BACE1LCKTP53TDP1
SCHEMBL13344899 0.83 CNR2 (0.61) CNR2TYRLCKTP53TDP1
SCHEMBL15257568 0.83 CNR2 (0.61) CNR2TYRLCKTP53TDP1
SCHEMBL27777637 0.82 TP53 (0.52) CNR2BACE1LCKTP53TDP1
SCHEMBL328541 0.82 LCK (0.73) CNR2TYRBACE1LCKTP53
SCHEMBL9746195 0.82 LCK (0.73) CNR2TYRBACE1LCKTP53
SCHEMBL30433974 0.82 LCK (0.73) CNR2TYRBACE1LCKTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180153785-A1 POLYHYDROXYLATED (1-PHENYL-2-PHENYL) ETHYLENE DERIVATIVES AS AN ANTI-AGEING AND PHOTOPROTECTIVE AGENT L'OREAL (FR) 2018-06-07 US disclosed
US-20180029952-A1 TOCOPHEROL STABILISERS FOR NITROCELLULOSE-BASED PROPELLANTS PB CLERMONT SA (BE) 2018-02-01 US disclosed
US-20180029951-A1 IONONE STABILISERS FOR NITROCELLULOSE-BASED PROPELLANTS PB CLERMONT SA (BE) 2018-02-01 US disclosed
US-20170362152-A1 NOVEL 1,2-DIPHENYLETHYLENE GLYCOL COMPOUNDS FOR COMBATING AGING OF THE SKIN, AND COSMETIC USE THEREOF L'OREAL (FR) 2017-12-21 US disclosed
US-20170152278-A1 Depolymerisation Of Lignin In Biomass BIOLEUM IP HOLDINGS LLC 2017-06-01 US disclosed
EP-2774969-A1 Process for converting bio-oil UPM-Kymmene Corporation (FI) 2014-09-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180029951-A1 IONONE STABILISERS FOR NITROCELLULOSE-BASED PROPELLANTS ACTN1, NDUFA10, NDUFA12 CNR2 4416/4885TYR 3106/4885BACE1 3448/4885
US-20170152278-A1 Depolymerisation Of Lignin In Biomass DCXR, LCT, MGAM CNR2 4380/4885TYR 200/4885BACE1 2844/4885
US-20180029952-A1 TOCOPHEROL STABILISERS FOR NITROCELLULOSE-BASED PROPELLANTS DCXR, TTPA, CBR1 CNR2 3405/4885TYR 1938/4885BACE1 3491/4885
US-20170362152-A1 NOVEL 1,2-DIPHENYLETHYLENE GLYCOL COMPOUNDS FOR COMBATING AGING OF THE SKIN, AND COSMETIC USE THEREOF GLA, DSG1, GPX1 CNR2 3527/4885TYR 27/4885BACE1 1557/4885
US-20180153785-A1 POLYHYDROXYLATED (1-PHENYL-2-PHENYL) ETHYLENE DERIVATIVES AS AN ANTI-AGEING AND PHOTOPROTECTIVE AGENT KRT18, GLA, CUTA CNR2 4172/4885TYR 79/4885BACE1 2502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.