Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918727 | 0.80 | HNF4A (0.49) | ALDH1A1L3MBTL1LMNAMAPTMYC | |
| SCHEMBL14919171 | 0.79 | MEN1 (0.51) | ALDH1A1L3MBTL1LMNAMAPTMYC | |
| SCHEMBL1535274 | 0.77 | RAB9A (0.46) | ALDH1A1L3MBTL1LMNAMAPTMYC | |
| SCHEMBL16037020 | 0.77 | ALDH1A1 (0.37) | ALDH1A1LMNABCAT2CA1CA2 | |
| SCHEMBL16038153 | 0.76 | TSHR (0.48) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL16039155 | 0.75 | AGTR2 (0.41) | — | |
| SCHEMBL29073837 | 0.75 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1LMNAMAPTMYC | |
| SCHEMBL14918728 | 0.75 | HNF4A (0.53) | ALDH1A1L3MBTL1LMNAMAPTMYC | |
| SCHEMBL28684912 | 0.72 | DHODH (0.39) | ALDH1A1L3MBTL1LMNAMAPTMYC | |
| SCHEMBL14918607 | 0.71 | TP53 (0.53) | ALDH1A1L3MBTL1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275049-A1 | SUBSTITUTED PYRAZOLE ANALOGS As RAR ANTAGONISTS | ELI LILLY AND COMPANY | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275049-A1 | SUBSTITUTED PYRAZOLE ANALOGS As RAR ANTAGONISTS | RARB, RARA, RARG | ALDH1A1 113/4885L3MBTL1 4725/4885LMNA 4594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.